ArticleFrontiers in human neuroscience2023
Changes in resting-state functional MRI connectivity during and after transcranial direct current stimulation in healthy adults.
Article in Frontiers in human neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Can exercise combined with transcranial direct current stimulation improve cognitive function in older adults? A systematic review and meta-analysis.Frontiers in neuroscience · 2026Pooled it
- Challenges and future directions of transcranial direct current stimulation for depression: insights from a systematic review and meta-analysis.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025Pooled it
- Improving locomotor performance with motor imagery and tDCS in young adults.Scientific reports · 2025Trial
- Impact of exercise-induced fatigue on the risk of stress fractures in the tibia during smash landing in female badminton players.Scientific reports · 2026Article
- The Effectiveness of Transcranial Direct Current Stimulation (tDCS) in Improving Performance in Soccer Players-A Scoping Review.Journal of clinical medicine · 2026Review
- Advanced imaging-integrated rTMS therapy for frontal network recovery after traumatic brain injury.Frontiers in human neuroscience · 2026Article
- Neural Correlates of Personality Traits in Adolescents Exhibiting Excessive Smartphone Use: A Resting-State FMRI Study.Life (Basel, Switzerland) · 2025Article
- Resting-State Activity Changes Induced by tDCS in MS Patients and Healthy Controls: A Simultaneous tDCS rs-fMRI Study.Bioengineering (Basel, Switzerland) · 2025Article
- The distinct and potentially conflicting effects of tDCS and tRNS on brain connectivity, cortical inhibition, and visuospatial memory.Frontiers in human neuroscience · 2024Article
- Simultaneous tDCS-fMRI reveals limited and inconsistent changes in functional connectivity: Insights from a temporal dynamics study.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Transcranial direct current stimulation (tDCS) applied over the dorsolateral prefrontal cortex (DLPFC) at rest can influence behaviors. However, its mechanisms remain poorly understood. This study examined the effect of a single session of tDCS over the bilateral DLPFC on resting-state functional connectivity using fMRI (rs-fcMRI) during and after stimulation in healthy adults. We also investigated whether baseline rs-fcMRI predicted tDCS-induced changes in rs-fcMRI. Methods: This was a randomized, sham-controlled, double-blind, crossover study. We delivered tDCS for 30 min at 1 mA with the anode and cathode over the left and right DLPFC, respectively. We used seed-based analyses to measure tDCS-induced effects on whole-brain rs-fcMRI using a 3 (before, during, after stimulation) × 2 (active, sham stimulation) ANOVA. Results: There were four significant Time × Stimulation interactions on the connectivity scores with the left DLPFC seed (under the anode electrode) and no interactions for the right DLPFC seed (under the cathode electrode). tDCS changed rs-fcMRI between the left DLPFC seed and parieto-occipital, parietal, parieto-occipitotemporal, and frontal clusters during and after stimulation, as compared to sham. Furthermore, rs-fcMRI prior to stimulation predicted some of these tDCS-induced changes in rs-fcMRI during and after stimulation. For instance, rs-fcMRI of the fronto-parietooccipital network predicted changes observed after active stimulation, rs-fcMRI of the fronto-parietal network predicted changes during active stimulation, whereas rs-fcMRI of the fronto-parieto-occipitotemporal and the frontal networks predicted changes both during and after active stimulation. Discussion: Our findings reveal that tDCS modulated rs-fcMRI both during and after stimulation mainly in regions distal, but also in those proximal to the area under the anode electrode, which were predicted by rs-fcMRI prior to tDCS. It might be worth considering rs-fcMRI to optimize response to tDCS.
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