ArticleJournal of neuromuscular diseases2023
Nerve Conduction Differences in a Large Clinical Population: The Role of Age and Sex.
Article in Journal of neuromuscular diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- AI-Based EMG Reporting: A Randomized Controlled Trial.Journal of neurology · 2025Trial
- Longitudinal multimodal assessment of peripheral nerve involvement in wild-type transthyretin amyloidosis.Journal of neurology · 2026Article
- Risk Factors of Sural Nerve Axonal Degeneration Using Clinically Relevant Thresholds in Context of Glucose Metabolism: The Maastricht Study.Muscle & nerve · 2026Article
- Behavioral and psychophysical characterization of proprioceptive impairment in healthy aging: a hyper-illusory experience of movement.npj aging · 2026Article
- Estimating paediatric normative values for nerve studies using clustering techniques.Clinical neurophysiology practice · 2026Article
- Ultrasonographic changes in median nerve cross-sectional area in the elderly: effects of aging and type 2 diabetes.BMC geriatrics · 2025Article
- Article
- Changes Over 10 Years in Peripheral Nerve Function in People With Well-Controlled Type 2 Diabetes and Those With Normal Glucose Tolerance.Neurology · 2025Observational
- Gender Differences in Nerve Conduction Parameters of Upper Limb Nerves in Healthy Adults: A Comparative Study.Journal of pharmacy & bioallied sciences · 2025Article
- A Prospective Comparison of Subjective Symptoms and Neurophysiological Findings in the Assessment of Neuropathy in Cancer Patients.Diagnostics (Basel, Switzerland) · 2024Article
- Electrodiagnostic Testing Predicts Postdecompression Outcomes in Patients With Cubital Tunnel Syndrome.Journal of hand surgery global online · 2024Article
- Characteristics of Patients with Clinical Signs and Symptoms of Carpal Tunnel Syndrome but Negative Diagnostic Testing.Plastic and reconstructive surgery. Global open · 2024Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe normal limits of nerve conduction studies are commonly determined by testing healthy subjects. However, in comprehensive real-life nerve conduction electrodiagnostic (EDX) evaluations, multiple nerves are tested, including normal nerves, for purposes of comparison with abnormal ones.
objectiveThis study aims to evaluate the average values of normal nerve conduction studies in a large population and examined the influence of age and sex.
methodsEDX parameters were extracted from an electronic database of studies performed from May 2016 to February 2022. Established normal values were used to determine the classification of a nerve study as normal.
resultsWe identified 10,648 EDX reports with 5077 normally interpreted nerve conduction studies (47.6%) of which 57% (n = 2890) were for females. The median age of studies with no abnormalities was 45.1 years (range < 1 to 92) overall and 42.5 years (range: 0.16 -89.5 years) for males and 47.5 years (range:<1 -91.7) for females. Correlations between age and amplitude, latency, and velocity (p < 0.001) were observed in most nerves. Amplitude correlated negatively with age in adults in all nerves with a mean of -0.44 (range: -0.24 to -0.62). However, in the pediatric population (age < 18 years), amplitude as well as velocity increased significantly with age. In the adult cohort, sex differences were noted, where females had higher mean sensory nerve action potentials in ulnar, median, and radial evaluations (p < 0.001). In older patients (aged > 70 years) with normally interpreted EDX studies (845 records of 528 patients), sural responses were present in 97%.
conclusionsThis real-life study confirms that advanced aging is associated with decreased nerve conduction amplitudes, increased latency, and the slowing of conduction velocity. The findings also indicate higher sensory amplitudes and conduction velocities in females. Sural nerve responses were identified in most adults over age 70.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.