Evidence map›Paper›PMID 37545215›Full record

ArticleCancer biomarkers : section A of Disease markers2024

Pan-cancer transcriptomic data of ABI1 transcript variants and molecular constitutive elements identifies novel cancer metastatic and prognostic biomarkers.

Tingru Lin, Jingzhu Guo, Yifan Peng, Mei Li, Yulan Liu, Xin Yu, Na Wu, Weidong Yu

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Article in Cancer biomarkers : section A of Disease markers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Tingru LinDepartment of Central Laboratory and Institute of Clinical Molecular Biology, Peking University People's Hospital, Beijing, China.
Jingzhu GuoDepartment of Pediatrics, Peking University People's Hospital, Beijing, China.
Yifan PengGastrointestinal Cancer Center, Unit III, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China.
Mei LiDepartment of Central Laboratory and Institute of Clinical Molecular Biology, Peking University People's Hospital, Beijing, China.
Yulan LiuDepartment of Gastroenterology, Peking University People's Hospital, Beijing, China.
Xin YuDepartment of Hepatobiliary Surgery, Peking University People's Hospital, Beijing, China.
Na WuDepartment of Central Laboratory and Institute of Clinical Molecular Biology, Peking University People's Hospital, Beijing, China.
Weidong YuDepartment of Central Laboratory and Institute of Clinical Molecular Biology, Peking University People's Hospital, Beijing, China.

Funding

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6 · The paper itself

Abstract

backgroundAbelson interactor 1 (ABI1) is associated with the metastasis and prognosis of many malignancies. The association between ABI1 transcript spliced variants, their molecular constitutive exons and exon-exon junctions (EEJs) in 14 cancer types and clinical outcomes remains unsolved.

objectiveTo identify novel cancer metastatic and prognostic biomarkers from ABI1 total mRNA, TSVs, and molecular constitutive elements.

methodsUsing data from TCGA and TSVdb database, the standard median of ABI1 total mRNA, TSV, exon, and EEJ expression was used as a cut-off value. Kaplan-Meier analysis, Chi-squared test (X2) and Kendall's tau statistic were used to identify novel metastatic and prognostic biomarkers, and Cox regression analysis was performed to screen and identify independent prognostic factors.

resultsA total of 35 ABI1-related factors were found to be closely related to the prognosis of eight candidate cancer types. A total of 14 ABI1 TSVs and molecular constitutive elements were identified as novel metastatic and prognostic biomarkers in four cancer types. A total of 13 ABI1 molecular constitutive elements were identified as independent prognostic biomarkers in six cancer types.

conclusionsIn this study, we identified 14 ABI1-related novel metastatic and prognostic markers and 21 independent prognostic factors in total 8 candidate cancer types.

Indexed as

NeoplasmsAdaptor Proteins, Signal TransducingBiomarkersBiomarkers, TumorCytoskeletal ProteinsGene Expression ProfilingHumansPrognosisRNA, MessengerABI1 protein, humanAdaptor Proteins, Signal TransducingBiomarkersBiomarkers, TumorCytoskeletal ProteinsRNA, MessengerABI1 transcript variantcancer biomarkermetastasismolecular constitutive elementprognosis

Identifiers

PMID37545215
PMCPMC10977443

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.