Evidence map›Paper›PMID 37544771›Full record

ArticleInternational journal of STD & AIDS2023

High level of HIV viral suppression in a cross-sectional study of Ugandan men with urethritis and bacterial STI.

Evan J Beck, Oliver Laeyendecker, Sharada Saraf, Swetha Ashokkumar, Annet Onzia, Johan H Melendez, Justin Chan, Peter Kyambadde, Ethan Gough, Rosalind Parkes-Ratanshi and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of STD & AIDS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Evan J BeckDivision of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-3292-3542
Oliver LaeyendeckerDivision of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Sharada SarafDivision of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Swetha AshokkumarDivision of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Annet OnziaInfectious Disease Institute, Makerere University, Kampala, Uganda.
Johan H MelendezDepartment of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Justin ChanDepartment of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Peter KyambaddeSTD and AIDS Control Programme, Ministry of Health of Uganda, Kampala, Uganda.
Ethan GoughDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Rosalind Parkes-RatanshiInfectious Disease Institute, Makerere University, Kampala, Uganda.ORCID 0000-0001-9297-1311
Yukari C ManabeDepartment of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Matthew M HamillDepartment of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-1277-819X
Johns Hopkins University · USNational Institutes of Health · USMakerere University · UGMinistry of Health · UG

Funding

TrainingU54EB007958 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Susan Anne Tuddenham · 2007 to 2026
$34.6M
International Center for Excellence in Research (ICER) in Uganda: Impact of ARVsZIAAI001040 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI REYNOLDS, STEVEN · 2009 to 2025
$23.5M
HIV Co-infections in Uganda: TB, Cryptococcus, and Viral Hepatitis.D43TW009771 · FIC · JOHNS HOPKINS UNIVERSITY · PI CASTELNUOVO, BARBARA, KAMBUGU, ANDREW DDUNGU · 2014 to 2023
$3.3M
FIC NIH HHS D43 TW009771NIBIB NIH HHS U54 EB007958
6 · The paper itself

Abstract

backgroundUrethritis associated with non-viral sexually transmitted infections (STI) increases the risk of HIV acquisition and transmission in those living with HIV (LWH) without viral load suppression (VLS). Compared to women, men typically have lower rates of HIV VLS. We assessed the prevalence of VLS and drug resistance mutations in men LWH and urethral discharge syndrome (UDS) in Kampala, Uganda.

methodsMen with UDS were recruited in Kampala October 2019-November 2020. Medical, demographic, and behavioural data were collected with biological samples. All reactive HIV results (rapid, sequential algorithm) underwent confirmatory HIV antibody- and HIV incidence-testing, and viral load (VL) measurement. The

results50 of 250 participants (20%) had reactive HIV rapid tests and 48/50 (96%) were aware of their HIV status and using antiretroviral therapy (ART). The median age was 38 years (IQR 32-45), 27/50 (54%) had engaged in transactional sex, and 30/50 (60%) reported alcohol before sex. VLS was present in 46/50 (92%). There were no major resistance mutations present in any samples analyzed.

conclusionsThe prevalence of HIV and VLS was greater in these men than in the general Ugandan adult population. Most men LWH were on ART and thus less likely to transmit HIV despite demonstrating sexual behaviours associated with high-risk of STIs. These data emphasize that high levels of ART coverage and VLS are achievable among men with UDS in urban Kampala.

Indexed as

HIV InfectionsSexually Transmitted DiseasesSexually Transmitted Diseases, BacterialUrethritisAdultCross-Sectional StudiesFemaleHumansMalePhylogenyUgandaViral Loadantiretroviral therapy resistancefactors associated with HIV transmissionHIV viral suppression, urethral discharge syndromemenrisk behaviourssexually transmitted infectionsUganda

Identifiers

PMID37544771
PMCPMC11361376
OpenAlexW4385613347

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.