Evidence map›Paper›PMID 37544298›Full record

ArticleCardiology2023

Cardiac Troponin T and NT-proBNP for Prediction of 30-Day Readmission or Death in Patients with Acute Dyspnea: Data from the Akershus Cardiac Examination 2 Study.

Rahul Bhatnagar, Kristian Berge, Ragnhild Røysland, Arne Didrik Høiseth, Jon Brynildsen, Geir Christensen, Torbjørn Omland, Helge Røsjø, Magnus Nakrem Lyngbakken

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Rahul BhatnagarDepartment of Cardiology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway, rahul.bhatnagar@studmed.uio.no.
Kristian BergeDepartment of Cardiology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway.
Ragnhild RøyslandInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Arne Didrik HøisethDepartment of Cardiology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway.
Jon BrynildsenDepartment of Cardiology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway.
Geir ChristensenInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Torbjørn OmlandDepartment of Cardiology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway.
Helge RøsjøK.G. Jebsen Center for Cardiac Biomarkers, University of Oslo, Oslo, Norway.
Magnus Nakrem LyngbakkenDepartment of Cardiology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway.
Akershus University Hospital · NOUniversity of Oslo · NOInstitutt for Eksperimentell Medisinsk Forskning · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionN-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) measurements are recommended in patients with acute dyspnea. We aimed to assess the prognostic merit of cTnT compared to NT-proBNP for 30-day readmission or death in patients hospitalized with acute dyspnea.

methodsWe measured cTnT and NT-proBNP within 24 h in 314 patients hospitalized with acute dyspnea and adjudicated the cause of the index admission. Time to first event of readmission or death ≤30 days after hospital discharge was recorded, and cTnT and NT-proBNP measurements were compared head-to-head.

resultsPatients who died (12/314) or were readmitted (71/314) within 30 days had higher cTnT concentrations (median: 32.6, Q1-Q3: 18.4-74.2 ng/L vs. median: 19.4, Q1-Q3: 8.4-36.1 ng/L; p for comparison <0.001) and NT-proBNP concentrations (median: 1,753.6, Q1-Q3: 464.2-6,862.0 ng/L vs. median 984, Q1-Q3 201-3,600 ng/L; for comparison p = 0.027) compared to patients who survived and were not readmitted. cTnT concentrations were associated with readmission or death within 30 days after discharge both in the total cohort (adjusted hazard ratio [aHR]: 1.64, 95% confidence interval [CI]: 1.30-2.05) and in patients with heart failure (HF) (aHR: 1.58, 95% CI: 1.14-2.18). In contrast, NT-proBNP concentrations were not associated with short-term events, neither in the total cohort (aHR: 1.10, 95% CI: 0.94-1.30) nor in patients with adjudicated HF (aHR: 1.06, 95% CI: 0.80-1.40).

conclusioncTnT concentrations are associated with 30-day readmission or death in patients hospitalized with acute dyspnea, as well as in patients adjudicated HF.

Indexed as

DyspneaNatriuretic Peptide, BrainPatient ReadmissionTroponin TAgedAged, 80 and overBiomarkersFemaleHumansKaplan-Meier EstimateMaleMiddle AgedPeptide FragmentsPredictive Value of TestsBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)TNNT2 protein, humanTroponin TAcute dyspneaCardiac troponin THeart FailureN-terminal pro-B-type natriuretic peptideReadmission

Identifiers

PMID37544298
PMCPMC10733942
OpenAlexW4385620265

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.