ArticleCell reports2023
Dopamine release at the time of a predicted aversive outcome causally controls the trajectory and expression of conditioned behavior.
Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Effects of KCNQ potassium channel modulation on ventral tegmental area activity and connectivity in individuals with depression and anhedonia.Molecular psychiatry · 2025Trial
- A ventral striatal learning signal reflecting individual differences in the success of fear extinction.Molecular psychiatry · 2026Article
- Article
- Dopamine Response to Unexpected Aversive Outcomes Drives the Return of Extinguished Fear.Brain sciences · 2026Article
- AAV-only targeting of ventral tegmental area dopamine neurons for optical self-stimulation studies in mice.Scientific reports · 2026Article
- Midbrain endocannabinoids actuate dopamine-based action selection.Cell reports · 2026Article
- Dopamine Dynamics in the Nucleus Accumbens Reflect Confidence in Detecting the Occurrence and Nonoccurrence of Visual Signals in Perceptual Decision-Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Dopamine and Acetylcholine in the Striatum: Circuit Interactions and Behavioral Control in Substance Use Disorders.Brain sciences · 2026Review
- AAV-only targeting of ventral tegmental area dopamine neurons for optical self-stimulation studies in mice.bioRxiv : the preprint server for biology · 2026Article
- Dorsolateral striatal acetylcholine reorganizes neural ensembles to anticipate threat.bioRxiv : the preprint server for biology · 2025Article
- Stimulation of CaScience signaling · 2025Article
- Dynamic changes of dopamine neuron activity and plasticity at different stages of negative reinforcement learning.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Fiber Photometry Analysis of Spontaneous Dopamine Signals: TheACS chemical neuroscience · 2025Article
- Caudate serotonin signaling during social exchange distinguishes essential tremor and Parkinson's disease patients.Nature communications · 2025Article
- Melanocortin 4 receptor-expressing neurons in the lateral stripe of the striatum regulate affect and motor control.iScience · 2025Article
- Altered Neural Activity in the Mesoaccumbens Pathway Underlies Impaired Social Reward Processing in Shank3-Deficient Rats.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Fiber photometry analysis of spontaneous dopamine signals: The z-scored data are not the data.bioRxiv : the preprint server for biology · 2025Article
- How Dopamine Enables Learning from Aversion.Current opinion in behavioral sciences · 2025Article
- Amplifying School Mental Health Literacy Through Neuroscience Education.Behavioral sciences (Basel, Switzerland) · 2024Review
- Combinatory Actions of Co-transmitters in Dopaminergic Systems ModulateThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Dopamine release in the nucleus accumbens (NAc) is causally linked to adaptive aversive learning, and its dysregulation is a core phenotype in anxiety and stress disorders. Here, we record NAc core dopamine during a task where mice learn to discriminate between cues signaling two types of outcomes: (1) footshock presentation and (2) footshock omission. We show that dopamine release is evoked by footshock omission. This dopamine response is largest when the omission is unexpected and decreases over learning, and artificially increasing this signal disrupts discrimination learning. Conversely, optogenetic inhibition of dopamine responses to the footshock itself impairs learning. Finally, theory-driven computational modeling suggests that these effects can be explained by dopamine signaling the perceived saliency of predicted aversive events. Together, we elucidate the role of NAc dopamine in aversive learning and offer potential avenues for understanding the neural mechanisms involved in anxiety and stress disorders.
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