Evidence map›Paper›PMID 37543909›Full record

ArticleArchives of Iranian medicine2022

Altered Expression of hsa_circ_0001445 and hsa_circ_0020397 in Breast Cancer Representing Associations with BMI and Reproductive Factors.

Zahra Firoozi, Elham Mohammadisoleimani, Hassan Dastsooz, Abdolreza Daraei, Seyed Alireza Dastgheib, Atefeh Raoofat, Hosein Mansoori, Yaser Mansoori, Mohammad Mehdi Naghizadeh

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In one paragraph

Article in Archives of Iranian medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Hsa_circ_0001445 regulates acne inflammationCentral-European journal of immunology · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Zahra FirooziDepartment of Medical Genetics, Fasa University of Medical Sciences, Fasa, Iran.ORCID 0000-0002-8103-2244
Elham MohammadisoleimaniDepartment of Medical Biotechnology, Fasa University of Medical Sciences, Fasa, Iran.
Hassan DastsoozIIGM-Italian Institute for Genomic Medicine, c/o IRCCS, Candiolo, Torino, Italy.ORCID 0000-0002-0679-4425
Abdolreza DaraeiDepartment of Medical Genetics, School of Medicine, Babol University of Medical Sciences, Babol, Iran.
Seyed Alireza DastgheibDepartment of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Atefeh RaoofatDepartment of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Hosein MansooriDepartment of Medical Genetics, Fasa University of Medical Sciences, Fasa, Iran.
Yaser MansooriDepartment of Medical Genetics, Fasa University of Medical Sciences, Fasa, Iran.ORCID 0000-0002-9101-5552
Mohammad Mehdi NaghizadehNoncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.ORCID 0000-0001-5562-103X
Fasa University of Medical Sciences · IRShiraz University of Medical Sciences · IRAccademia Albertina delle Belle Arti · ITBabol University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCircular RNAs (circRNAs), one of the recent subclasses of non-coding RNAs (ncRNAs), show pivotal functions in regulation of gene expression and have significant roles in malignancies including breast cancer (BC). This study was aimed to assess the hsa_circ_0001445 and hsa_circ_0020397 expression and role in BC, as well as the potential circRNA/miRNA/mRNA crosstalk in these contexts.

methodsThe expression of hsa_circ_0001445 and hsa_circ_0020397 in 50 breast tumors and 50 normal tissues adjacent to the tumors was investigated using quantitative real-time polymerase chain reaction (qRT-PCR). Finally, bioinformatics analyses were used to uncover hsa_circ_0001445, hsa_circ_0020397-miRNA-mRNA potential regulatory networks.

resultsThe hsa_circ_0001445 expression was considerably downregulated in malignant tissues compared to their normal counterparts (

conclusionIt is suggested that hsa_circ_0001445 and hsa_circ_0020397 with two opposite roles may be involved in BC development through sponging some miRNAs regulating ceRNA networks. However, their molecular interactions should be validated by further functional studies.

Indexed as

Breast NeoplasmsMicroRNAsAdolescentBody Mass IndexFemaleHumansRNA, CircularRNA, MessengerMicroRNAsRNA, CircularRNA, MessengerBreast CancerCircular RNAsHsa_circ_0001445Hsa_circ_0020397

Identifiers

PMID37543909
PMCPMC10685847
OpenAlexW4366214696

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.