Evidence map›Paper›PMID 37543887›Full record

Trial reportArchives of Iranian medicine2022

Clinical Evaluation of an HTK Solution for Liver Transplantation: A Phase 3 Randomized Pilot Clinical Trial Study.

Seyed Ali Malekhosseini, Younes Ghasemi, Javad Rousta, Roghayyeh Aghaei, Sedigheh Kianpour, Manica Negahdaripour, Reza Heidari, Alireza Shamsaeefar, Siavash Gholami, Saman Nikeghbalian

Open access · hybridAbstract readRandomized Controlled TrialClinical Trial, Phase III
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Archives of Iranian medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Seyed Ali MalekhosseiniShiraz Transplant Center, Abu Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID 0000-0002-0853-9938
Younes GhasemiPharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID 0000-0003-4172-0672
Javad RoustaPharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Roghayyeh AghaeiPharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Sedigheh KianpourPharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Manica NegahdaripourPharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID 0000-0002-4265-1499
Reza HeidariPharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Alireza ShamsaeefarShiraz Transplant Center, Abu Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Siavash GholamiShiraz Transplant Center, Abu Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Saman NikeghbalianShiraz Transplant Center, Abu Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID 0000-0003-4530-8829
Shiraz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOrgan preservation solutions are not easily accessible in Iran, similar to many resource-limited countries. We aimed to evaluate the efficacy of a locally-produced HTK solution among adult liver transplantation candidates in a pilot clinical trial study.

methodsAdult patients undergoing liver transplantation were randomly allocated into two groups. One received the HTK solution (PharMedCina Inc., Shiraz, Iran), and the second received the commercially available HTK solution (Custodiol

resultsOverall, 28 individuals entered the study, including 11 and 9 males (78.6% and 64.3%) in the Custodiol

conclusionBased on the findings of this pilot study with the current sample size, no statistically significant difference was found between our locally-produced HTK solution and Custodiol

Indexed as

Liver TransplantationOrgan Preservation SolutionsAdultGlucoseGlutathioneHumansInsulinLiverMaleMannitolOrgan PreservationPilot ProjectsPotassium ChlorideProcaineBretschneider cardioplegic solutionGlucoseGlutathioneInsulinMannitolOrgan Preservation SolutionsPotassium ChlorideProcaineClinical trialHTKOrgan transplantationPreservation solutionPrognosisTransplantation

Identifiers

PMID37543887
PMCPMC10685771
OpenAlexW4313729302

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.