Evidence map›Paper›PMID 37543621›Full record

ArticleNature communications2023

Combined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors.

Alessandra Castiglioni, Yagai Yang, Katherine Williams, Alvin Gogineni, Ryan S Lane, Amber W Wang, Justin A Shyer, Zhe Zhang, Stephanie Mittman, Alan Gutierrez and 21 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
19.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 84 citations in OpenAlex.

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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 2 institutions in 2 countries.

Alessandra Castiglioni *Genentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-1761-9761
Yagai Yang *Genentech, South San Francisco, CA, USA.
Katherine Williams *Genentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-8061-0105
Alvin GogineniGenentech, South San Francisco, CA, USA.
Ryan S LaneGenentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-6788-3560
Amber W WangGenentech, South San Francisco, CA, USA.
Justin A ShyerGenentech, South San Francisco, CA, USA.
Zhe ZhangGenentech, South San Francisco, CA, USA.ORCID http://orcid.org/0009-0000-3689-477X
Stephanie MittmanGenentech, South San Francisco, CA, USA.
Alan GutierrezGenentech, South San Francisco, CA, USA.
Jillian L AstaritaGenentech, South San Francisco, CA, USA.
Minh ThaiGenentech, South San Francisco, CA, USA.
Jeffrey HungGenentech, South San Francisco, CA, USA.
Yeqing Angela YangGenentech, South San Francisco, CA, USA.
Tony PourmohamadGenentech, South San Francisco, CA, USA.
Patricia HimmelsGenentech, South San Francisco, CA, USA.
Marco De SimoneGenentech, South San Francisco, CA, USA.
Justin ElstrottGenentech, South San Francisco, CA, USA.
Aude-Hélène CapiettoGenentech, South San Francisco, CA, USA.
Rafael CubasGenentech, South San Francisco, CA, USA.
Zora ModrusanGenentech, South San Francisco, CA, USA.
Wendy SandovalGenentech, South San Francisco, CA, USA.
James ZiaiGenentech, South San Francisco, CA, USA.
Stephen E GouldGenentech, South San Francisco, CA, USA.
Wenxian FuGenentech, South San Francisco, CA, USA.
Yulei WangGenentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-9057-9786
James T KoerberGenentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-7756-972X
Shomyseh SanjabiGenentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3097-9665
Ira MellmanGenentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-6132-7299
Shannon J TurleyGenentech, South San Francisco, CA, USA. Turley.Shannon@gene.com.ORCID http://orcid.org/0000-0002-0444-3031
Sören MüllerGenentech, South San Francisco, CA, USA. Muller.Soren@gene.com.ORCID http://orcid.org/0000-0001-9490-5270
Genesys (United States) · USGene Therapy Laboratory · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TGFβ signaling is associated with non-response to immune checkpoint blockade in patients with advanced cancers, particularly in the immune-excluded phenotype. While previous work demonstrates that converting tumors from excluded to inflamed phenotypes requires attenuation of PD-L1 and TGFβ signaling, the underlying cellular mechanisms remain unclear. Here, we show that TGFβ and PD-L1 restrain intratumoral stem cell-like CD8 T cell (T

Indexed as

B7-H1 AntigenCD8-Positive T-LymphocytesImmune Checkpoint InhibitorsTransforming Growth Factor betaUrinary Bladder NeoplasmsAnimalsBreast NeoplasmsCell DifferentiationCell Line, TumorFemaleInterferon-gammaMiceMice, Inbred BALB CRNA-SeqStem CellsT-Cell ExhaustionB7-H1 AntigenImmune Checkpoint InhibitorsInterferon-gammaTransforming Growth Factor beta

Identifiers

PMID37543621
PMCPMC10404279
OpenAlexW4385597052

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.