Evidence map›Paper›PMID 37543620›Full record

ArticleNature communications2023

Self-supervised learning with application for infant cerebellum segmentation and analysis.

Yue Sun, Limei Wang, Kun Gao, Shihui Ying, Weili Lin, Kathryn L Humphreys, Gang Li, Sijie Niu, Mingxia Liu, Li Wang

Abstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yue SunDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID http://orcid.org/0000-0003-3151-6774
Limei WangDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Kun GaoDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Shihui YingDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Weili LinDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID http://orcid.org/0000-0002-2900-8204
Kathryn L HumphreysDepartment of Psychology and Human Development, Vanderbilt University, Nashville, TN, 37203, USA.ORCID http://orcid.org/0000-0002-5715-6597
Gang LiDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID http://orcid.org/0000-0001-9585-1382
Sijie NiuDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Mingxia LiuDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. mxliu@med.unc.edu.ORCID http://orcid.org/0000-0002-0598-5692
Li WangDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. li_wang@med.unc.edu.ORCID http://orcid.org/0000-0003-2165-0080

Funding

Continued Development of Infant Brain Analysis ToolsR01MH117943 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, GANG, WANG, LI · 2018 to 2022
$2.3M
Parcellating Infant Cerebral Cortex based on Developmental Patterns of Multimodal MRIR01MH116225 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, GANG · 2018 to 2022
$1.9M
Multi-Site Neuroimage Harmonization for Personalized Brain Disorder AnalysisRF1AG073297 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, MINGXIA · 2022 to 2022
$1.4M
Multi-Site Neuroimage Harmonization for Personalized Brain Disorder AnalysisR01AG073297 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mingxia Liu · 2025 to 2026
$922k
Harmonizing and Archiving of Large-scale Infant Neuroimaging DataRF1MH123202 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, GANG · 2021 to 2021
$627k
Volume-based Analysis of 6-month Infant Brain MRI for Autism Biomarker Identification and Early DiagnosisK01MH109773 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WANG, LI · 2017 to 2020
$571k
NIA NIH HHS R01 AG073297NIA NIH HHS RF1 AG073297NIMH NIH HHS K01 MH109773NIMH NIH HHS R01 MH116225NIMH NIH HHS R01 MH117943NIMH NIH HHS RF1 MH123202
6 · The paper itself

Abstract

Accurate tissue segmentation is critical to characterize early cerebellar development in the first two postnatal years. However, challenges in tissue segmentation arising from tightly-folded cortex, low and dynamic tissue contrast, and large inter-site data heterogeneity have limited our understanding of early cerebellar development. In this paper, we propose an accurate self-supervised learning framework for infant cerebellum segmentation. We validate its accuracy using 358 subjects from three datasets. Our results suggest the first six months exhibit the most rapid and dynamic changes, with gray matter (GM) playing a dominant role in cerebellar growth over white matter (WM). We also find both GM and WM volumes are larger in males than females, and GM and WM volumes are larger in autistic males than neurotypical males. Application of our method to a larger population will fuel more cerebellar studies, ultimately advancing our comprehension of its structure and function in neurotypical and disordered development.

Indexed as

Magnetic Resonance ImagingWhite MatterBrainCerebellumFemaleGray MatterHumansInfantMaleSupervised Machine Learning

Identifiers

PMID37543620
PMCPMC10404262

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.