Evidence map›Paper›PMID 37543537›Full record

ArticleGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2023

Endoscopic differential diagnosis between foveolar-type gastric adenoma and gastric hyperplastic polyps in Helicobacter pylori-naïve patients.

Kotaro Shibagaki, Norihisa Ishimura, Satoshi Kotani, Chika Fukuyama, Yusuke Takahashi, Kenichi Kishimoto, Tomotaka Yazaki, Masatoshi Kataoka, Taisuke Omachi, Yasuhito Kinoshita and 10 more

Open access · bronzeAbstract read
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In one paragraph

Article in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Gastric neoplasm with foveolar-cell differentiation inHistology and histopathology · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. A mathematical simulation model to determine the optimal endoscopic screening strategy for detection of H. pylori-naïve gastric neoplasms.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 2 institutions in 1 country.

Kotaro ShibagakiDepartment of Endoscopy, Shimane University Hospital, 89-1 Enya, Izumo, Shimane, 693-8501, Japan. kotaro@med.shimane-u.ac.jp.ORCID http://orcid.org/0000-0003-3583-2707
Norihisa IshimuraDepartment of Gastroenterology, Faculty of Medicine, Shimane University, Izumo, Japan.
Satoshi KotaniDepartment of Gastroenterology, Faculty of Medicine, Shimane University, Izumo, Japan.
Chika FukuyamaDepartment of Gastroenterology, Faculty of Medicine, Shimane University, Izumo, Japan.
Yusuke TakahashiDepartment of Gastroenterology, Faculty of Medicine, Shimane University, Izumo, Japan.
Kenichi KishimotoDepartment of Gastroenterology, Faculty of Medicine, Shimane University, Izumo, Japan.
Tomotaka YazakiDepartment of Gastroenterology, Faculty of Medicine, Shimane University, Izumo, Japan.
Masatoshi KataokaDepartment of Gastroenterology, Faculty of Medicine, Shimane University, Izumo, Japan.
Taisuke OmachiDepartment of Gastroenterology, Faculty of Medicine, Shimane University, Izumo, Japan.
Yasuhito KinoshitaDepartment of Gastroenterology, Faculty of Medicine, Shimane University, Izumo, Japan.
Nobuaki HasegawaDepartment of Gastroenterology, Faculty of Medicine, Shimane University, Izumo, Japan.
Akihiko OkaDepartment of Gastroenterology, Faculty of Medicine, Shimane University, Izumo, Japan.
Yoshiyuki MishimaDepartment of Gastroenterology, Faculty of Medicine, Shimane University, Izumo, Japan.
Tsuyoshi MishiroDepartment of Gastroenterology, Faculty of Medicine, Shimane University, Izumo, Japan.
Naoki OshimaDepartment of Gastroenterology, Faculty of Medicine, Shimane University, Izumo, Japan.
Kousaku KawashimaDepartment of Gastroenterology, Faculty of Medicine, Shimane University, Izumo, Japan.
Mamiko NagaseDepartment of Pathology, Faculty of Medicine, Shimane University, Izumo, Japan.
Asuka ArakiDepartment of Pathology, Faculty of Medicine, Shimane University, Izumo, Japan.
Kyuichi KadotaDepartment of Pathology, Faculty of Medicine, Shimane University, Izumo, Japan.
Shunji IshiharaDepartment of Gastroenterology, Faculty of Medicine, Shimane University, Izumo, Japan.
Shimane University · JPShimane University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFoveolar-type gastric adenoma (FGA) occurs in Helicobacter pylori (Hp)-naïve individuals and morphologically mimics Hp-naïve gastric hyperplastic polyp (HpN-GHP). FGA is often difficult to distinguish from HpN-GHP even by biopsy, due to its low-grade histologic atypia. We conducted a retrospective study to create an endoscopic diagnostic index.

methodsWe analyzed 51 FGAs in 41 patients and 36 HpN-GHPs in 24 patients. All lesions were photographed by white-light endoscopy (WLE) and narrow-band imaging with magnification endoscopy (NBIME). Three experts and three non-experts reviewed the WLE and WLE+NBIME images to assess six items for lesion diagnosis. We analyzed correlations between the diagnostic items and histologic features and compared the diagnostic accuracy between modalities. We created a composite diagnostic index and calculated its accuracy and consistency.

resultsFGAs more frequently showed the following features vs. HpN-GHPs: bright-red color (94.1% vs. 44.4%), peripheral hyperplasia (58.8% vs. 8.3%), papillary/gyrus-like microstructure (96.1% vs. 33.3%), visible capillaries (70.6% vs. 38.9%), and demarcation line (98.0% vs. 41.7%) (P < 0.05). White-zone thickening was seen only in HpN-GHPs (52.8%). Diagnostic accuracy (mean, WLE vs. WLE+NBIME) was 90.8 ± 1.1% vs. 93.5 ± 2.4% (P = 0.15) for experts and 88.5 ± 3.0% vs. 86.6 ± 3.5% (P = 0.51) for non-experts. When satisfying the four criteria (bright-red color, papillary/gyrus-like microstructure, demarcation line, and absent white-zone thickening), sensitivity and specificity for FGA were 90.2% and 94.4%, respectively, with a kappa value of ≥ 0.6 for interobserver diagnostic agreement.

conclusionsComposite diagnostic index contributes to the reproducible, accurate, preoperative differential diagnosis of FGA and HpN-GHP.

Indexed as

Adenomatous PolypsHelicobacter pyloriStomach NeoplasmsDiagnosis, DifferentialGastroscopyHumansRetrospective StudiesFoveolar-type gastric adenomaGastric hyperplastic polypHelicobacter pyloriRaspberry-like appearance

Identifiers

PMID37543537
OpenAlexW4385605669

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.