Evidence map›Paper›PMID 37543305›Full record

ArticleHeart rhythm2023

SUMOylation of the cardiac sodium channel Na

Jin-Young Yoon, Alexander M Greiner, Julia S Jacobs, Young-Rae Kim, Tyler P Rasmussen, William J Kutschke, Daniel S Matasic, Ajit Vikram, Ravinder R Gaddam, Haider Mehdi and 2 more

Open access · greenAbstract read
In one paragraph

Article in Heart rhythm, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Jin-Young YoonDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa, Iowa City, Iowa; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Alexander M GreinerDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa, Iowa City, Iowa.
Julia S JacobsDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa, Iowa City, Iowa.
Young-Rae KimDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa, Iowa City, Iowa.
Tyler P RasmussenDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa, Iowa City, Iowa.
William J KutschkeDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa, Iowa City, Iowa.
Daniel S MatasicDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa, Iowa City, Iowa.
Ajit VikramDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa, Iowa City, Iowa; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Ravinder R GaddamDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa, Iowa City, Iowa; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Haider MehdiDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa, Iowa City, Iowa; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Kaikobad IraniDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa, Iowa City, Iowa; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa; Fraternal Order of Eagles Diabetes Research Center, Pappajohn Biomedical Institute, and Heart and Vascular Center, University of Iowa, Iowa City, Iowa. Electronic address: kaikobad-irani@uiowa.edu.
Barry LondonDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa, Iowa City, Iowa; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa. Electronic address: barry-london@uiowa.edu.
University of Iowa · US

Funding

SUMOylation of Voltage-Gated Sodium Channels In Neuronal Hyperexcitability of Alzheimer’s DementiaR01HL115955 · NHLBI · UNIVERSITY OF IOWA · PI IRANI, KAIKOBAD J., LONDON, BARRY · 2013 to 2023
$5.4M
The SIRT1-Gpd1L-NAD+ interactome in regulation of the Neuronal Sodium Channel: Implications for Cognitive Impairment of Alzheimer’s DementiaR01HL147545 · NHLBI · UNIVERSITY OF IOWA · PI BRENNER, CHARLES M, IRANI, KAIKOBAD J. · 2019 to 2022
$2.9M
SIRTUIN1-mediated inhibition of p66shc lysine acetylation as a novel treatment for diabetic vasculopathyI01BX002940 · VA · PROVIDENCE VA MEDICAL CENTER · PI IRANI, KAIKOBAD J. · 2016 to 2024
–
American Heart Association-American Stroke Association 23CDA1052321BLRD VA I01 BX002940NHLBI NIH HHS R01 HL115955NHLBI NIH HHS R01 HL147545
6 · The paper itself

Abstract

backgroundDecreased peak sodium current (I

objectiveThe purpose of this study was to determine whether and by what mechanisms SUMOylation alters I

methodsSUMOylation of Na

resultsNa

conclusionSUMOylation of K442-Na

Indexed as

Myocytes, CardiacSumoylationAnacardic AcidsAnimalsArrhythmias, CardiacHEK293 CellsHumansMiceNAV1.5 Voltage-Gated Sodium ChannelRatsSodiumSodium Channelsanacardic acidAnacardic AcidsNAV1.5 Voltage-Gated Sodium ChannelScn5a protein, mouseSodiumSodium ChannelsArrhythmiaNa(V)1.5SENPSodium currentSUMOylation

Identifiers

PMID37543305
PMCPMC12007604
OpenAlexW4385515608

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.