Evidence map›Paper›PMID 37543275›Full record

ArticleBioorganic & medicinal chemistry letters2023

Discovery of 1,3-disubstituted pyrazole peripheral cannabinoid receptor partial agonists.

George Amato, Scott Runyon, Vineetha Vasukuttan, Ann M Decker, Elaine A Gay, Lucas Laudermilk, Rangan Maitra

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

George AmatoDiscovery Sciences, RTI International, 3040 Cornwallis Rd., Research Triangle Park, NC 27709-2194, USA.
Scott RunyonDiscovery Sciences, RTI International, 3040 Cornwallis Rd., Research Triangle Park, NC 27709-2194, USA.
Vineetha VasukuttanDiscovery Sciences, RTI International, 3040 Cornwallis Rd., Research Triangle Park, NC 27709-2194, USA.
Ann M DeckerDiscovery Sciences, RTI International, 3040 Cornwallis Rd., Research Triangle Park, NC 27709-2194, USA.
Elaine A GayDiscovery Sciences, RTI International, 3040 Cornwallis Rd., Research Triangle Park, NC 27709-2194, USA.
Lucas LaudermilkDiscovery Sciences, RTI International, 3040 Cornwallis Rd., Research Triangle Park, NC 27709-2194, USA.
Rangan MaitraDiscovery Sciences, RTI International, 3040 Cornwallis Rd., Research Triangle Park, NC 27709-2194, USA. Electronic address: rmaitra@rti.org.
RTI International · US

Funding

Investigation of Synthetic Cannabinoid Exposures and Pharmacological ConsequencesR01DA040460 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI RANGAN MAITRA, Yanan Zhang · 2016 to 2026
$4.5M
Novel therapeutic approach for NASHR01DK124615 · NIDDK · RESEARCH TRIANGLE INSTITUTE · PI MAITRA, RANGAN · 2020 to 2023
$2.1M
NIDA NIH HHS R01 DA040460NIDDK NIH HHS R01 DK124615
6 · The paper itself

Abstract

Partial agonists of peripheral cannabinoid receptors (CBRs) have potential therapeutic applications in several medical conditions. However, (-)-trans-Δ

Indexed as

Cannabinoid Receptor AgonistsDronabinolPyrazolesReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2Receptors, CannabinoidTissue DistributionCannabinoid Receptor AgonistsDronabinolPyrazolesReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2Receptors, CannabinoidAgonistCannabinoidCB1CB2CompoundPeripheral

Identifiers

PMID37543275
PMCPMC10529378
OpenAlexW4385568066

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.