Evidence map›Paper›PMID 37542721›Full record

ArticleCell reports2023

Evolution of two distinct variable lymphocyte receptors in lampreys: VLRD and VLRE.

Sabyasachi Das, Thomas Boehm, Stephen J Holland, Jonathan P Rast, Francisco Fontenla-Iglesias, Ryo Morimoto, J Gerardo Valadez, Ryan D Heimroth, Masayuki Hirano, Max D Cooper

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sabyasachi DasDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA; Emory Vaccine Center, Emory University, Atlanta, GA 30317, USA. Electronic address: sdas8@emory.edu.
Thomas BoehmDepartment of Developmental Immunology, Max-Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany; Faculty of Medicine, University of Freiburg, Breisacher Str. 153, 79110 Freiburg, Germany. Electronic address: boehm@ie-freiburg.mpg.de.
Stephen J HollandDepartment of Developmental Immunology, Max-Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany.
Jonathan P RastDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA; Emory Vaccine Center, Emory University, Atlanta, GA 30317, USA.
Francisco Fontenla-IglesiasDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA; Emory Vaccine Center, Emory University, Atlanta, GA 30317, USA.
Ryo MorimotoDepartment of Developmental Immunology, Max-Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, 79108 Freiburg, Germany.
J Gerardo ValadezDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA; Emory Vaccine Center, Emory University, Atlanta, GA 30317, USA.
Ryan D HeimrothDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA; Emory Vaccine Center, Emory University, Atlanta, GA 30317, USA.
Masayuki HiranoDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA; Emory Vaccine Center, Emory University, Atlanta, GA 30317, USA.
Max D CooperDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA; Emory Vaccine Center, Emory University, Atlanta, GA 30317, USA. Electronic address: mdcoope@emory.edu.

Funding

Characterization of the Lamprey Adaptive Immune SystemR01AI072435 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Max Dale Cooper · 2007 to 2026
$8.1M
T Cell Differentiation and Diversification in Jawless Vertebrates: Administrative Supplement for purchase of Laser Capture MicroscopeR35GM122591 · NIGMS · EMORY UNIVERSITY · PI Max Dale Cooper · 2017 to 2026
$4.7M
Characterization of an Alternative Adaptive Immune System in HagfishR01GM108838 · NIGMS · EMORY UNIVERSITY · PI COOPER, MAX DALE · 2014 to 2016
$889k
NIAID NIH HHS R01 AI072435NIGMS NIH HHS R01 GM108838NIGMS NIH HHS R35 GM122591
6 · The paper itself

Abstract

Jawless vertebrates possess an alternative adaptive immune system in which antigens are recognized by variable lymphocyte receptors (VLRs) generated by combinatorial assembly of leucine-rich repeat (LRR) cassettes. Three types of receptors, VLRA, VLRB, and VLRC, have been previously identified. VLRA- and VLRC-expressing cells are T cell-like, whereas VLRB-expressing cells are B cell-like. Here, we report two types of VLRs in lampreys, VLRD and VLRE, phylogenetically related to VLRA and VLRC. The germline VLRD and VLRE genes are flanked by 39 LRR cassettes used in the assembly of mature VLRD and VLRE, with cassettes from chromosomes containing the VLRA and VLRC genes also contributing to VLRD and VLRE assemblies. VLRD and VLRE transcription is highest in the triple-negative (VLRA

Indexed as

LampreysLymphocytesAnimalsAntigensB-LymphocytesReceptors, AntigenT-LymphocytesAntigensReceptors, Antigenadaptive immunityCP: GenomicsCP: Immunologygene conversionimmune system evolutionjawless vertebratesleucine-rich repeatsvariable lymphocyte receptor

Identifiers

PMID37542721
PMCPMC11160967

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.