Evidence map›Paper›PMID 37542654›Full record

SynthesisEuropean radiology2024

Normal pediatric values of carotid artery intima-media thickness measured by B-mode ultrasound and radiofrequency echo tracking respecting the consensus: a systematic review.

Jean-Baptiste Moretti, Reinemary Michael, Sylvie Gervais, Émilie Alchourron, Nina Stein, Ziad Farhat, Chantal Lapierre, Josée Dubois, Ramy El-Jalbout

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in European radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Jean-Baptiste MorettiMontreal University, Montreal, Canada. jean-baptiste.moretti@umontreal.ca.ORCID http://orcid.org/0000-0003-1502-3232
Reinemary MichaelLaval University, Quebec City, Canada.
Sylvie GervaisÉcole de Technologie Supérieure, Montreal, Canada.
Émilie AlchourronMontreal University, Montreal, Canada.
Nina SteinMcMaster Children's Hospital, Hamilton, Canada.
Ziad FarhatIWK Health Dalhousie University, Halifax Regional Municipality, Nova Scotia, Canada.
Chantal LapierreMedical Imaging Department, Sainte-Justine University Hospital and Research Center, Montreal, QC, Canada.
Josée DuboisMedical Imaging Department, Sainte-Justine University Hospital and Research Center, Montreal, QC, Canada.
Ramy El-JalboutMedical Imaging Department, Sainte-Justine University Hospital and Research Center, Montreal, QC, Canada.
Centre Hospitalier Universitaire Sainte-Justine · CADalhousie University · CAÉcole de Technologie Supérieure · CAMcMaster Children's Hospital · CAUniversité de Montréal · CAUniversité Laval · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCarotid artery intima-media thickness (IMT) is a sub-clinical radiologic marker of atherosclerosis in children. It is associated with adult-onset vascular disease.

objectiveTo determine normal pediatric values of IMT from results observed in the literature.

methodsOur systematic review was conducted according to PRISMA guidelines. We reviewed 2298 English articles from inception to February 2023. Inclusion criteria included studies evaluating B-mode and radiofrequency (RF)-based IMT measurements based on the American Heart Association, the Association for European Pediatric Cardiology, the Mannheim Consensus, and the American Society of Echocardiography recommendations. A meta-analysis of aggregate data was conducted to obtain the confidence interval (CI) for IMT, using a 95% confidence level.

resultsWe obtained 88 B-mode-based IMT measurement studies with 6184 children and six radiofrequency echo-tracking-based studies with 766 children. Mean IMT in the pediatric population was 0.43 mm, 95% [CI] 0,42 to 0.44, using the B-mode technique, and 0.41 mm, 95% [CI] 0.36 to 0.45 using the radiofrequency technique. No significant relationship was detected between IMT and age (p value = 0.83). Finally, no significant effect of sex on IMT was found (p value = 0.82 for B-mode and p value = 0.62 for RF).

conclusionBased on the studies selected in this literature review, we were unable to conclude that there was a significant difference between the average IMT of boys and girls. No relationship was demonstrated between age and IMT. IMT is technique-specific, and normal values should be interpreted according to recommendations of recognized consensus to counteract the current heterogeneity in literature. CLINICAL RELEVANCE STATEMENT: Technique and children-specific Intima media thickness measurements help clinicians and scientists to assess the risk of atherosclerosis in children. KEY POINTS: • Intima-media thickness (IMT) does not correlate with age in children without risk factors. • According to current literature, there is no difference in IMT between healthy boys and girls. • There is heterogeneity, even with studies abiding by the official consensus.

Indexed as

AtherosclerosisCarotid Intima-Media ThicknessAdultCarotid ArteriesChildConsensus Statements as TopicFemaleHumansMaleReference ValuesRisk FactorsUltrasonographyCardiovascular riskCarotid intima-media thicknessPediatricRadiologyUltrasound

Identifiers

PMID37542654
OpenAlexW4385607099

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.