Observational studyAging clinical and experimental research2023
Frailty and post-operative delirium influence on functional status in patients with hip fracture: the GIOG 2.0 study.
Observational study in Aging clinical and experimental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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The trial behind it
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Unraveling the impact of frailty on postoperative delirium in elderly surgical patients: a systematic review and meta-analysis.BMC anesthesiology · 2025Pooled it
- Impact of frailty on postoperative complications in older adults after hip fracture: a systematic review of observational studies.Frontiers in medicine · 2025Pooled it
- The Current Status of Frailty and Influencing Factors in Elderly Patients With Hip Fractures: A Meta-Analysis.BioMed research international · 2025Pooled it
- Trial
- Comparative Analysis of the ASA-PS Score and Clinical Frailty Scale in Predicting Postoperative Intensive Care Unit Requirement in Geriatric Hip Fracture Surgery: A Retrospective Evaluation.Journal of clinical medicine · 2026Article
- Association of pre- and postoperative delirium with functional status at discharge after hip fracture: findings from the Gruppo Italiano di Ortogeriatria (GIOG 2.0) study.European geriatric medicine · 2026Article
- Associations of postoperative delirium with perioperative frailty worsening and their combined effect on 1-year mortality in older surgical patients: a prospective cohort study.European geriatric medicine · 2026Article
- Underuse of osteoporosis treatments before and after hip fracture: longitudinal findings from the Gruppo Italiano di Ortogeriatria (GIOG 2.0) study.Frontiers in aging · 2026Article
- Observational
- Hip Fracture as a Systemic Disease in Older Adults: A Narrative Review on Multisystem Implications and Management.Medical sciences (Basel, Switzerland) · 2025Review
- The effect of delirium on the association between frailty and postoperative major complications in elderly patients: a mediation analysis.Journal of anesthesia · 2025Article
- Deprescribing psychoactive drugs in older orthogeriatric patients: findings from the GIOG2.0 Italian survey.BMC geriatrics · 2025Observational
- Independent Association Between Frailty and Fear of Falling in Older Adults After Hip Fracture Surgery: A Cross-Sectional Study Using a Secondary Analysis.Nursing research and practice · 2025Article
- Exploring Sex-Related Difference in Cerebrospinal Fluid/Blood Quotient of Albumin in Older Patients Undergoing Hip Fracture Surgery: Insight From the ORTODEL and BIODEL Study.Biomarker insights · 2025Article
- Predictors of non-adherence to an early in-hospital rehabilitation program after surgery for hip fracture in a co-managed orthogeriatric unit.Aging clinical and experimental research · 2024Observational
- Comment on the association of preoperative frailty with the risk of postoperative delirium in older patients undergoing hip fracture surgery: a prospective cohort study.Aging clinical and experimental research · 2024Article
- Factors associated with delirium in a real-world acute-care setting: analysis considering the interdependence of clinical variables with the frailty syndrome.European geriatric medicine · 2024Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study analyzes the effect of frailty and Post-Operative Delirium (POD) on the functional status at hospital discharge and at 4-month follow-up in patients with hip fracture (HF).
methodsMulticenter prospective observational study of older patients with HF admitted to 12 Italian Orthogeriatric centers (July 2019-August 2022). POD was assessed using the 4AT. A 26-item Frailty Index (FI) was created using data collected on admission. The outcome measures were Cumulated Ambulation Score (CAS) ≤ 2 at discharge and a telephone-administered CAS ≤ 2 after 4 months. Poisson regression models were used to assess the effect of frailty and POD on outcomes.
results984 patients (median age 84 years, IQR = 79-89) were recruited: 480 (48.7%) were frail at admission, 311 (31.6%) developed POD, and 158 (15.6%) had both frailty and POD. In a robust Poisson regression, frailty alone (Relative Risk, RR = 1.56, 95% Confidence Intervals, CI 1.19-2.04, p = 0.001) and its combination with POD (RR = 2.57, 95% CI 2.02-3.26, p < 0.001) were associated with poor functional status at discharge. At 4-month follow-up, the combination of frailty with POD (RR 3.65, 95% CI 1.85-7.2, p < 0.001) increased the risk of poor outcome more than frailty alone (RR 2.38, 95% CI 1.21-4.66, p < 0.001).
conclusionsPOD development exacerbates the negative effect that frailty exerts on functional outcomes in HF patients.
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