ArticleBiochemistry2023
Synergistic Binding of the Halide and Cationic Prime Substrate of l-Lysine 4-Chlorinase, BesD, in Both Ferrous and Ferryl States.
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Article in Biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
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Who cites it
10 citing papers in PubMed, 10 citations in OpenAlex.
- Experimental and Computational Elucidation of C(sp3)-H Fluorination Barriers in an Iron(II)- and 2-Oxoglutarate-Dependent Halogenase.Journal of the American Chemical Society · 2026Article
- How Fe(II)/2-Oxoglutarate Oxygenase Chooses Chlorination over Hydroxylation: Electric Field-Driven Ligand Exchange Governs C-Cl Formation.Journal of the American Chemical Society · 2026Article
- Total Synthesis of (+)-12-The Journal of organic chemistry · 2026Article
- Review
- Dynamic metal coordination controls chemoselectivity in a radical halogenase.Nature chemical biology · 2026Article
- Examining Pseudohalide (NJournal of inorganic biochemistry · 2026Article
- Regio- and Stereoselective Halogenation by an Iron(II)- and 2-Oxoglutarate-Dependent Halogenase in the Biosynthesis of Halogenated Nucleosides.Journal of the American Chemical Society · 2025Article
- Tracing the stepwise Darwinian evolution of a plant halogenase.Science advances · 2025Article
- Machine Learning Guided Rational Design of a Non-Heme Iron-Based Lysine Dioxygenase Improves its Total Turnover Number.Chembiochem : a European journal of chemical biology · 2024Article
- An Unusual Ferryl Intermediate and Its Implications for the Mechanism of Oxacyclization by the Loline-Producing Iron(II)- and 2-Oxoglutarate-Dependent Oxygenase, LolO.Biochemistry · 2024Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Jeffrey W SlaterDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID 0000-0002-1126-8905
Chi-Yun LinDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID 0000-0001-6555-8767
Monica E NeugebauerDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, California 94720, United States.
Molly J McBrideDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID 0000-0003-3832-1355
Debangsu SilDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID 0000-0002-0718-3925
Mrutyunjay A NairDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Bryce J KatchDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Amie K BoalDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID 0000-0002-1234-8472
Michelle C Y ChangDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, California 94720, United States.ORCID 0000-0003-3747-7630
Alexey SilakovDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID 0000-0002-9285-1253
Carsten KrebsDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID 0000-0002-3302-7053
J Martin BollingerDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID 0000-0003-0751-8585
Pennsylvania State University · USLawrence Berkeley National Laboratory · USUniversity of California, Berkeley · US
Funding
Mapping the Structural Basis for Mechanistic Diversity in Metalloenzyme SuperfamiliesR35GM119707 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Amie K Boal · 2016 to 2026
$5.0MMechanisms of Mononuclear non-Heme-Iron EnzymesR35GM127079 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI CARSTEN KREBS · 2018 to 2026
$3.8MDiscovery and Application of New HalogenasesR01GM134271 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHANG, MICHELLE C · 2020 to 2023
$1.5MThe role of geometric structure in avoidance of oxygen rebound to enable aliphatic halogenation and oxacyclization by non-heme Fe(IV)-oxo (ferryl) complexesR01GM141284 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI SILAKOV, ALEXEY · 2022 to 2025
$1.5MStructures and Mechanisms of “Heme-oxygenase-like” Non-heme Di-iron Enzymes that Catalyze Complex N-oxygenation and Olefin-installing C–C-Fragmentation ReactionsR01GM138580 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI BOLLINGER, JOSEPH M · 2020 to 2023
$1.3MInterrogating the Haloferryl State of Iron(II)- and 2-Oxoglutarate-Dependent Halogenases through Mimicry and Active Site ModificationsF32GM136156 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI SLATER, JEFFREY WORTHINGTON · 2020 to 2022
$201kNIGMS NIH HHS F32 GM136156NIGMS NIH HHS R01 GM134271NIGMS NIH HHS R01 GM138580NIGMS NIH HHS R01 GM141284NIGMS NIH HHS R35 GM119707NIGMS NIH HHS R35 GM127079
Abstract
An aliphatic halogenase requires four substrates: 2-oxoglutarate (2OG), halide (Cl
Indexed as
ChloridesLysineIronMixed Function OxygenasesOxidation-ReductionOxygenChloridesIronLysineMixed Function OxygenasesOxygen
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