ArticleBMC surgery2023
Risk factors analysis for clinical symptoms of prenatally diagnosed choledochal cysts: a retrospective study.
Article in BMC surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- MRI features of fetal type I congenital choledochal cyst and parameter measurement of hepatobiliary development.BMC medical imaging · 2026Article
- Predictive value of cyst size for clinical symptoms in patients with prenatally diagnosed choledochal cysts.Translational pediatrics · 2026Article
- Surgical outcomes in neonates and infants with congenital choledochal malformation: analysis of the Pediatric Health Information System (PHIS) database.Pediatric surgery international · 2026Article
- Early Definitive Surgery for Congenital Biliary Dilatation in Children Is Associated With Lower Morbidity: Comparison of Infant and School-Age Children From 231 Consecutive Cases in a Multicenter Study in the Kyushu Area of Japan During the Past Decade.Journal of hepato-biliary-pancreatic sciences · 2025Article
- Comparative analysis of Da Vinci robotic surgery and laparoscopic surgery for congenital choledochal cyst in neonates.BMC pediatrics · 2025Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to screen the impact factors for clinical symptoms of prenatally diagnosed choledochal cysts (CDCs), to warn about the occurrence of clinical symptoms and the timing of surgery.
methodsMedical records of patients with prenatally diagnosed CDCs admitted to our hospital from April 2013 to April 2018 were retrospectively reviewed. Fetal hilar or abdominal cysts were found by prenatal ultrasonogram. All patients underwent laparoscopic cyst excision and hepaticojejunostomy in our center. Univariate analysis and multivariate logistic regression analysis were performed to screen the factors related to clinical symptoms intimately.
resultsTwo hundred eighteen cases were included. One hundred thirty-four patients (134/218, 61.5%) presented clinical symptoms before surgery. The results of univariate analysis showed that patients with clinical symptoms had earlier time of prenatal diagnosis (P = 0.002), higher values of GGT, TBIL, DBIL (P < 0.001, P < 0.001, P < 0.001, respectively) and larger maximum diameter of cyst before surgery (P = 0.012). Multivariate logistic regression analysis suggested that the time of prenatal diagnosis (P = 0.001, OR = 0.898, 95% CI: 0.845 ~ 0.955) and the GGT value within one week of life (P = 0.028, OR = 1.002, 95% CI: 1.000 ~ 1.003) were independent influencing factors for symptoms.
conclusionsFor children with prenatally diagnosed CDCs, approximately 2/3 patients presented noticeable clinical symptoms before surgery. The time of prenatal diagnosis and the GGT value within 1 week of life were independent impact factors for the occurrence of clinical symptoms.
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