Evidence map›Paper›PMID 37542232›Full record

Trial reportBMC oral health2023

Potential use of optical coherence tomography in oral potentially malignant disorders: in-vivo case series study.

Alessio Gambino, Eugenio Martina, Vera Panzarella, Tiziana Ruggiero, Giorgia El Haddad, Roberto Broccoletti, Paolo G Arduino

Erratum issuedOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC oral health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Alessio GambinoDepartment of Surgical Sciences, CIR Dental School, University of Turin, Via Nizzan.230, 10123, Turin, Italy. alessio.gambino@unito.it.
Eugenio MartinaDepartment of Surgical Sciences, CIR Dental School, University of Turin, Via Nizzan.230, 10123, Turin, Italy.
Vera PanzarellaDepartment of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo, Italy.
Tiziana RuggieroDepartment of Surgical Sciences, CIR Dental School, University of Turin, Via Nizzan.230, 10123, Turin, Italy.
Giorgia El HaddadDepartment of Surgical Sciences, CIR Dental School, University of Turin, Via Nizzan.230, 10123, Turin, Italy.
Roberto BroccolettiDepartment of Surgical Sciences, CIR Dental School, University of Turin, Via Nizzan.230, 10123, Turin, Italy.
Paolo G ArduinoDepartment of Surgical Sciences, CIR Dental School, University of Turin, Via Nizzan.230, 10123, Turin, Italy.
University of Turin · ITUniversity of Palermo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEvidence confirms that the use of Optical Coherence Tomography (OCT) in oral medicine can be a reliable aid for the diagnosis and management of Oral Potentially Malignant Disorders (OPMDs). Several authors described the ability of this system to detect the structural changes of the epithelia involved by the OPMDs. The purpose of this case series is to provide a suggestion for interpretation of OCT images from different OPMDs, compared to OCT images of healthy tissues.

methodsA sample of 11 OPMDs patients was recruited and analyzed with OCT. The images obtained were then compared with an OCT repertoire image. In this work the reflectance degree was considered, together with the analysis of the increased/decreased thicknesses of the various layers. Keratin Layer (KL), Epithelial Layer (EP), Lamina Propria (LP), Basal Membrane (BM) assessment, for each lesion, was performed.

resultsOCT measurements of KL, EP and LP layers, together with BM assessing, should aid the physicians to recognize and describe different oral lesions, relating them to the corresponding oral pathology.

conclusionMore studies like this, on larger samples, are needed to validate the results and provide, in the future, a kind of manual that could guide clinicians to correctly interpret the OCT images in relation to the causing pathologies.

trial registrationThe present trial has been registered with ISRCTN (#17,893,224).

Indexed as

Mouth DiseasesTomography, Optical CoherenceEpitheliumHumansResearch DesignOptical coherence tomographyOral cancerOral potential malignant disordersOral soft tissue

Identifiers

PMID37542232
PMCPMC10403886
OpenAlexW4385576912

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.