Evidence map›Paper›PMID 37542155›Full record

Observational studyJournal of perinatology : official journal of the California Perinatal Association2023

Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study.

Charles E Green, Jon E Tyson, Roy J Heyne, Susan R Hintz, Betty R Vohr, Carla M Bann, Abhik Das, Edward F Bell, Sana Boral Debsareea, Emily Stephens and 32 more

Registry-linked trialOpen access · hybridAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of perinatology : official journal of the California Perinatal Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00063063 (Generic Database), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00063063 recruitingnot on this map

Generic Database: A Survey of Morbidity and Mortality in Very Low Birth Weight Infants

TypeobservationalSponsorNICHD Neonatal Research NetworkRan1987 to 2030Enrolled80,000ConditionsInfant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, PrematureArmsNo Intervention
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors at 20 institutions in 1 country.

Charles E GreenDepartment of Pediatrics, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA. Charles.Green@uth.tmc.edu.
Jon E TysonDepartment of Pediatrics, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.
Roy J HeyneDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Susan R HintzDepartment of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA, USA.ORCID 0000-0001-7023-4433
Betty R VohrDepartment of Pediatrics, Women & Infants Hospital, Brown University, Providence, RI, USA.ORCID 0000-0003-1200-7413
Carla M BannSocial, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, Greensboro, NC, USA.
Abhik DasSocial, Statistical and Environmental Sciences Unit, RTI International, Rockville, MD, USA.
Edward F BellDepartment of Pediatrics, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-5568-0889
Sana Boral DebsareeaCenter for Clinical Research and Evidence-Based Medicine, University of Texas Houston McGovern Medical School, Houston, TX, USA.
Emily StephensDepartment of Pediatrics, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.
Marie G GantzSocial, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, Greensboro, NC, USA.
Carolyn M Petrie HuitemaSocial, Statistical and Environmental Sciences Unit, RTI International, Rockville, MD, USA.
Karen J JohnsonDepartment of Pediatrics, University of Iowa, Iowa City, IA, USA.
Kristi L WatterbergUniversity of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Ricardo MosqueraChildren's Memorial Hermann Hospital, Houston, TX, USA.
Myriam Peralta-CarcelenDivision of Neonatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Deanne E Wilson-CostelloDepartment of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH, USA.
Tarah T ColaizyDepartment of Pediatrics, University of Iowa, Iowa City, IA, USA.
Nathalie L MaitreDepartment of Pediatrics, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH, USA.
Stephanie L MerharDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Ira Adams-ChapmanEmory University School of Medicine, Department of Pediatrics, Children's Healthcare of Atlanta, Atlanta, GA, USA.
Janell FullerDepartment of Pediatrics, University of New Mexico, Albuquerque, NM, USA.
Michelle E Hartley-McAndrewDepartment of Pediatrics, University of Buffalo, Buffalo, NY, USA.
William F MalcolmDepartment of Pediatrics, Duke University, Durham, NC, USA.
Sarah WinterDepartment of Pediatrics, Division of Neonatology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Andrea F DuncanDepartment of Pediatrics, Pennsylvania Hospital, Philadelphia, PA, USA.ORCID 0000-0002-5973-2690
Gary J MyerUniversity of Rochester School of Medicine and Dentistry, Rochester, NY, USA.ORCID 0000-0003-4317-015X
Stephen D KicklighterDepartment of Pediatrics, Wake Medical Center, Raleigh, NC, USA.ORCID 0000-0003-3091-9547
Myra H WyckoffDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Sara B DeMauroDepartment of Pediatrics, University of Pennsylvania, Philadelphia, PA, USA.
Anna Maria HibbsDepartment of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH, USA.
Barbara J StollDepartment of Pediatrics, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.
Waldemar A CarloDivision of Neonatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Krisa P Van MeursDepartment of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA, USA.
Matthew A RysavyDepartment of Pediatrics, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-1209-6607
Ravi M PatelEmory University School of Medicine, Department of Pediatrics, Children's Healthcare of Atlanta, Atlanta, GA, USA.ORCID 0000-0002-7444-5550
Pablo J SánchezDepartment of Pediatrics, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH, USA.ORCID 0000-0003-2437-1247
Abbot R LaptookDepartment of Pediatrics, Women & Infants Hospital, Brown University, Providence, RI, USA.ORCID 0000-0001-9848-3466
C Michael CottenDepartment of Pediatrics, Duke University, Durham, NC, USA.
Carl T D'AngioDepartment of Pediatrics, Wake Medical Center, Raleigh, NC, USA.
Michele C WalshEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Nationwide Children's Hospital · USWomen & Children's Hospital of Buffalo · USMemorial Hermann · USPrimary Children's Hospital · USDuke University · USUniversity of Alabama System · USUniversity of Iowa · USLucile Packard Children's Hospital · USBrown University · USParkland Health & Hospital System · USGrady Memorial Hospital · USRTI International · USChildren's Hospital of Philadelphia · USUniversity of New Mexico · USCincinnati Children's Hospital Medical Center · USRainbow Babies & Children's Hospital · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USThe University of Texas Health Science Center at Houston · USEmory University · USThe University of Texas Southwestern Medical Center · US

Funding

Neonatal Research Network Data Coordinating Center (DCC) 2023-2028U24HD095254 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI Abhik Das · 2018 to 2026
$70.2M
Duke CTSA (Composite)UL1TR001117 · NCATS · DUKE UNIVERSITY · PI BOULWARE, LEIGH E, LI, JENNIFER S · 2013 to 2017
$41.3M
NICHD Neonatal Research Network -- Cincinnati Clinical CenterUG1HD027853 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI STEPHANIE L MERHAR · 2016 to 2026
$3.7M
NICHD COPPERATIVE MULTICENTER NEONATAL RESEARCH NETWORKUG1HD040689 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI Myra Helen Wyckoff · 2016 to 2026
$3.5M
NICHD Cooperative Multicenter Neonatal Research Network - Utah CenterUG1HD087226 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ROBIN K OHLS · 2016 to 2026
$3.3M
NICHD Neonatal Research Network - Stanford UniversityUG1HD027880 · NICHD · STANFORD UNIVERSITY · PI Valerie Chock · 2016 to 2026
$3.3M
Eunice Kennedy Shriver NICHD Cooperative Multicenter Neonatal ResearchNetworkUG1HD053089 · NICHD · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Janell Fuller, Jessie R. Maxwell · 2016 to 2026
$3.2M
NICHD Neonatal Research NetworkUG1HD027851 · NICHD · EMORY UNIVERSITY · PI Ravi Mangal Patel · 2016 to 2026
$3.0M
Rochester-Buffalo Neonatal Research GroupUG1HD068263 · NICHD · UNIVERSITY OF ROCHESTER · PI BLISS, JOSEPH MARK · 2016 to 2024
$1.6M
NICHD Neonatal Research Network (NRN): Clinical Centers (UG1 Clinical Trial OptionalUG1HD112093 · NICHD · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Matthew Albert Rysavy · 2023 to 2026
$1.4M
NCATS NIH HHS UL1 TR001117NICHD NIH HHS U24 HD095254NICHD NIH HHS UG1 HD027851NICHD NIH HHS UG1 HD027853NICHD NIH HHS UG1 HD027880NICHD NIH HHS UG1 HD040689NICHD NIH HHS UG1 HD053089NICHD NIH HHS UG1 HD068263NICHD NIH HHS UG1 HD087226
6 · The paper itself

Abstract

objectiveExtremely preterm (EP) impairment rates are likely underestimated using the Bayley III norm-based thresholds scores and may be better assessed relative to concurrent healthy term reference (TR) infants born in the same hospital. STUDY

designBlinded, certified examiners in the Neonatal Research Network (NRN) evaluated EP survivors and a sample of healthy TR infants recruited near the 2-year assessment age.

resultsWe assessed 1452 EP infants and 183 TR infants. TR-based thresholds showed higher overall EP impairment than Bayley norm-based thresholds (O.R. = 1.86; [95% CI 1.56-2.23], especially for severe impairment (36% vs. 24%; p ≤ 0.001). Difficulty recruiting TR patients at 2 years extended the study by 14 months and affected their demographics.

conclusionImpairment rates among EP infants appear to be substantially underestimated from Bayley III norms. These rates may be best assessed by comparison with healthy term infants followed with minimal attrition from birth in the same centers. CLINICALTRIALS: GOV ID: Term Reference (under the Generic Database Study): NCT00063063.

Indexed as

Child DevelopmentInfant, Extremely PrematureDatabases, FactualHumansInfantInfant, Newborn

Identifiers

PMID37542155
PMCPMC10615749
OpenAlexW4385576280

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.