ArticleScientific reports2023
Endocrine, inflammatory and immune responses and individual differences in acute hypobaric hypoxia in lowlanders.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07624409 (Physical and Nutritional Exercise Program Protocol for the Improvement of the Health Determinants of a Population That Works in Conditions of Intermittent Hypobaric Hypoxia), which is not on this map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Physical and Nutritional Exercise Program Protocol for the Improvement of the Health Determinants of a Population That Works in Conditions of Intermittent Hypobaric Hypoxia
Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Acclimatization Effects ofInternational journal of molecular sciences · 2026Article
- An acute pelvic pain in high-altitude tourist: A case report of ruptured ectopic pregnancy with low β-human chorionic gonadotropin.Medicine · 2025Article
- Low temperature abolishes human cellular circadian rhythm through Hopf bifurcation.NPJ systems biology and applications · 2025Article
- High-altitude hypoxia exacerbates chemotherapy-induced myelosuppression by lowering serum G-CSF/GM-CSF and regulating apoptosis and proliferation.Discover oncology · 2025Article
- Estrogen via GPER downregulated HIF-1a and MIF expression, attenuated cardiac arrhythmias, and myocardial inflammation during hypobaric hypoxia.Molecular medicine (Cambridge, Mass.) · 2025Article
- Article
- Neurological Biomarker Profiles in Royal Canadian Air Force (RCAF) Pilots and Aircrew.Brain sciences · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When lowlanders are exposed to environments inducing hypobaric hypoxia (HH) such as high mountains, hemodynamic changes occur to maintain oxygen levels in the body. However, changes to other physiological functions under such conditions have yet to be clarified. This study investigated changes in endocrine, inflammatory and immune parameters and individual differences during acute HH exposure using a climatic chamber (75 min of exposure to conditions mimicking 3500 m) in healthy lowlanders. Aldosterone and cortisol were significantly decreased and interleukin (IL)-6, IL-8 and white blood cell (WBC) counts were significantly increased after HH. Lower peripheral oxygen saturation (SpO
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Registered trials
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