ArticleTranslational psychiatry2023
Hypothalamus volume mediates the association between adverse childhood experience and PTSD development after adulthood trauma.
Article in Translational psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Childhood emotional maltreatment and trauma-related outcomes: a systematic review and multilevel meta-analysis.European journal of psychotraumatology · 2026Pooled it
- Repairing Attachment Insecurities with God and PTSD Symptomology in Adult Survivors of Childhood Trauma: An Exploratory Study Using Spiritually Integrated Cognitive Processing Therapy (SICPT).Journal of religion and health · 2026Article
- PTSD symptoms, loneliness, and amygdala volumes during pandemic social distancing associated with risk of suicidal ideation in trauma survivors with and without pre-pandemic PTSD.Journal of affective disorders reports · 2026Article
- Trauma and post-traumatic stress symptoms among internally displaced populations in Yemen: evidence from a mixed-methods study.Conflict and health · 2026Article
- Pre-trauma hair cortisol moderates adverse childhood experience and hypothalamic volume effects on stress symptoms after adult trauma.Translational psychiatry · 2026Article
- Hypothalamus volumes and mental health in children and adolescents.Frontiers in neuroscience · 2026Article
- Optimizing Symptom Surveys with Machine Learning to Predict PTSD One Year Post-trauma....IEEE...International Conference on Connected Health: Applications, Systems and Engineering Technologies. IEEE International Conference on Connected Health: Applications, Systems and Engineering Technologies · 2026Article
- Adolescent tickling incorporating handling is associated with reduced stress- and fear-related behaviors in socially isolated male rats.Frontiers in behavioral neuroscience · 2026Article
- Predicting PTSD development with early post-trauma assessments: a proof-of-concept for a concise tree-based classification method.European journal of psychotraumatology · 2025Article
- COVID-19 Pandemic Impacts on STRESS, PTSD, and Prefrontal Cortical Thickness in Pre-Pandemic Trauma Survivors.Journal of personalized medicine · 2025Article
- Common and sex-specific differences in hypothalamic subunit volumes and their links with depressive symptoms in treatment-naïve patients with major depressive disorder.Brain structure & function · 2025Article
- Post-traumatic stress disorder: evolving conceptualization and evidence, and future research directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Minimizing Survey Questions for PTSD Prediction Following Acute Trauma.Artificial intelligence in medicine. Conference on Artificial Intelligence in Medicine (2005- ) · 2024Article
- Hypothalamic Subunit Volumes in Schizophrenia and Bipolar Spectrum Disorders.Schizophrenia bulletin · 2024Article
- Neuroanatomical and functional correlates in post-traumatic stress disorder: A narrative review.Ibrain · 2024Review
- Randomized controlled trial investigating web-based, therapist delivered eye movement desensitization and reprocessing for adults with suicidal ideation.Frontiers in psychiatry · 2024Article
- Adverse childhood experiences, brain function, and psychiatric diagnoses in a large adult clinical cohort.Frontiers in psychiatry · 2024Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The hypothalamus is critical for regulation of the hypothalamic-pituitary-adrenal (HPA) axis and response to stress. Adverse childhood experience (ACE) can affect brain structure, which may contribute to development of posttraumatic stress disorder (PTSD) after subsequent adult trauma. It is unclear, however, if ACE history is particularly associated with aspects of hypothalamic structure which contribute to development of PTSD. To address this issue, the present study longitudinally assessed hypothalamic volumes and their associations with ACE and early post-trauma stress symptoms in subjects who did or did not develop PTSD during 12 months after adult trauma. 109 subjects (18-60 years, F/M = 75/34) completed the PTSD Checklist (PCL) questionnaire for post-trauma stress symptoms, the Childhood Trauma Questionnaire (CTQ) for ACE assessment, and an initial MRI brain scan for hypothalamic volume measurement, within 2 weeks after adult trauma. At post-trauma 12 months, subjects underwent a subsequent PTSD diagnosis interview using the Clinician-Administered PTSD Scale (CAPS), and a follow-up MRI scan. Left and right hypothalamus volumes at 2 weeks after adult trauma negatively correlated with CTQ scores. Right hypothalamus volume at this early time mediated an association between ACE and PTSD symptoms 12 months later. Right hypothalamus volumes also remained persistently smaller from 2 weeks to 12 months after trauma in survivors who developed PTSD. These results suggest that smaller right hypothalamus volume may be related to ACE history in ways that contribute to PTSD development after trauma in adulthood.
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