Evidence map›Paper›PMID 37541951›Full record

Trial reportBritish journal of anaesthesia2023

Subanaesthetic doses of ketamine reduce but do not eliminate predictive coding responses: implications for mechanisms of sensory disconnection.

Jordan J Wehrman, Cameron Casey, Sean Tanabe, Sounak Mohanta, William Filbey, Lilian Weber, Matthew I Banks, Robert A Pearce, Yuri Saalmann, Robert D Sanders

Registry-linked trialOpen access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of anaesthesia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03284307 (UNderstanding CONSciousness Connectedness and Intraoperative Unresponsiveness Study), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03284307 phase4completednot on this map

UNderstanding CONSciousness Connectedness and Intraoperative Unresponsiveness Study

TypeinterventionalSponsorUniversity of Wisconsin, MadisonRan2017 to 2020Enrolled35ConditionsUnconsciousness, ConsciousnessArmsDexmedetomidine, Ketamine, Propofol, Midazolam
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Jordan J WehrmanCentral Clinical School, Faculty of Medicine and Health, Sydney, NSW, Australia; Department of Anaesthetics, Royal Prince Alfred Hospital, Sydney Local Health District, Sydney, NSW, Australia.
Cameron CaseyDepartment of Anesthesiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Sean TanabeCenter for Consciousness Science, Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
Sounak MohantaDepartment of Psychology, University of Wisconsin, Madison, WI, USA.
William FilbeyDepartment of Anesthesiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Lilian WeberWellcome Centre for Integrative Neuroimaging, Department of Psychiatry, University of Oxford, Oxford, UK; Oxford Centre for Human Brain Activity (OHBA) University Department of Psychiatry, Warneford Hospital, Oxford, UK.
Matthew I BanksDepartment of Anesthesiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Robert A PearceDepartment of Anesthesiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Yuri SaalmannDepartment of Psychology, University of Wisconsin, Madison, WI, USA.
Robert D SandersCentral Clinical School, Faculty of Medicine and Health, Sydney, NSW, Australia; Department of Anaesthetics, Royal Prince Alfred Hospital, Sydney Local Health District, Sydney, NSW, Australia; Institute of Academic Surgery, Royal Prince Alfred Hospital, Sydney Local Health District, Sydney, NSW, Australia; NHMRC Clinical Trials Centre, The University of Sydney, Sydney, NSW, Australia. Electronic address: robert.sanders@sydney.edu.au.
University of Wisconsin–Madison · USRoyal Prince Alfred Hospital · AUThe University of Sydney · AUUniversity of Michigan · USWarneford Hospital · GB

Funding

Thalamic and cortical mechanisms of anesthetic-induced unconsciousnessR01GM109086 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Matthew I Banks, Kirill V Nourski · 2014 to 2026
$5.7M
6 · The paper itself

Abstract

backgroundSensory disconnection is a key feature of sleep and anaesthesia. We have proposed that predictive coding offers a framework for understanding the mechanisms of disconnection. Low doses of ketamine that do not induce disconnection should thus diminish predictive coding, but not abolish it.

methodsKetamine was administered to 14 participants up to a blood concentration of 0.3 μg ml

resultsKetamine modulated prediction errors associated with the transition of one tone to the next (transitional probability), but not how often tones changed (environmental volatility), of the system. Transitional probability was reduced when blood concentrations of ketamine were increased to 0.2-0.3 μg ml

conclusionsSubanaesthetic dosing of ketamine reduced correlates of predictive coding but did not eliminate them. Future studies should evaluate whether states of sensory disconnection, including anaesthetic doses of ketamine, are associated with a complete absence of predictive coding responses. CLINICAL

trial registrationNCT03284307.

Indexed as

AnesthesiaKetamineBayes TheoremElectroencephalographyEvoked PotentialsHumansKetamineelectroencephalographyhierarchical Gaussian filterketaminemismatch negativityNMDApredictive codingsensory disconnection

Identifiers

PMID37541951
PMCPMC10624770
OpenAlexW4385479847

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.