Evidence map›Paper›PMID 37541841›Full record

ArticleNeurology2023

Association of Olfaction and Microstructural Integrity of Brain Tissue in Community-Dwelling Adults: Atherosclerosis Risk in Communities Neurocognitive Study.

Srishti Shrestha, Xiaoqian Zhu, Kevin J Sullivan, Chad Blackshear, Jennifer A Deal, A Richey Sharrett, Vidyulata Kamath, Andrea L C Schneider, Clifford R Jack, Juebin Huang and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Cerebral Small Vessel Disease in Older Adults With Olfactory Dysfunction.International forum of allergy & rhinology · 2025
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Srishti ShresthaFrom the The Memory Impairment and Neurodegenerative Dementia (MIND) Center (S.S., X.Z., K.J.S., C.B., J.H., B.G.W., M.E.G., T.H.M.), University of Mississippi Medical Center, Jackson; Department of Epidemiology (J.A.D., A.R.S.), Johns Hopkins University Bloomberg School of Public Health; Department of Psychiatry and Behavioral Sciences (V.K.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology (A.L.C.S.), and Department of Biostatistics, Epidemiology, and Informatics (A.L.C.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Radiology (C.R.J., R.I.R.), Mayo Clinic, Rochester, MN; Department of Neurology (J.H.), University of Mississippi Medical Center, Jackson; Department of Neurology (P.P.), University of North Carolina at Chapel Hill; Department of Neurology (D.S.K.), Mayo Clinic, Rochester, MN; Stroke Branch (R.F.G.), National Institute of Neurological Disorders and Stroke Intramural Research Program, Bethesda, MD; and Department of Epidemiology and Biostatistics (H.C.), Michigan State University, East Lansing. sshrestha1@umc.edu.
Xiaoqian ZhuFrom the The Memory Impairment and Neurodegenerative Dementia (MIND) Center (S.S., X.Z., K.J.S., C.B., J.H., B.G.W., M.E.G., T.H.M.), University of Mississippi Medical Center, Jackson; Department of Epidemiology (J.A.D., A.R.S.), Johns Hopkins University Bloomberg School of Public Health; Department of Psychiatry and Behavioral Sciences (V.K.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology (A.L.C.S.), and Department of Biostatistics, Epidemiology, and Informatics (A.L.C.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Radiology (C.R.J., R.I.R.), Mayo Clinic, Rochester, MN; Department of Neurology (J.H.), University of Mississippi Medical Center, Jackson; Department of Neurology (P.P.), University of North Carolina at Chapel Hill; Department of Neurology (D.S.K.), Mayo Clinic, Rochester, MN; Stroke Branch (R.F.G.), National Institute of Neurological Disorders and Stroke Intramural Research Program, Bethesda, MD; and Department of Epidemiology and Biostatistics (H.C.), Michigan State University, East Lansing.
Kevin J SullivanFrom the The Memory Impairment and Neurodegenerative Dementia (MIND) Center (S.S., X.Z., K.J.S., C.B., J.H., B.G.W., M.E.G., T.H.M.), University of Mississippi Medical Center, Jackson; Department of Epidemiology (J.A.D., A.R.S.), Johns Hopkins University Bloomberg School of Public Health; Department of Psychiatry and Behavioral Sciences (V.K.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology (A.L.C.S.), and Department of Biostatistics, Epidemiology, and Informatics (A.L.C.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Radiology (C.R.J., R.I.R.), Mayo Clinic, Rochester, MN; Department of Neurology (J.H.), University of Mississippi Medical Center, Jackson; Department of Neurology (P.P.), University of North Carolina at Chapel Hill; Department of Neurology (D.S.K.), Mayo Clinic, Rochester, MN; Stroke Branch (R.F.G.), National Institute of Neurological Disorders and Stroke Intramural Research Program, Bethesda, MD; and Department of Epidemiology and Biostatistics (H.C.), Michigan State University, East Lansing.
Chad BlackshearFrom the The Memory Impairment and Neurodegenerative Dementia (MIND) Center (S.S., X.Z., K.J.S., C.B., J.H., B.G.W., M.E.G., T.H.M.), University of Mississippi Medical Center, Jackson; Department of Epidemiology (J.A.D., A.R.S.), Johns Hopkins University Bloomberg School of Public Health; Department of Psychiatry and Behavioral Sciences (V.K.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology (A.L.C.S.), and Department of Biostatistics, Epidemiology, and Informatics (A.L.C.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Radiology (C.R.J., R.I.R.), Mayo Clinic, Rochester, MN; Department of Neurology (J.H.), University of Mississippi Medical Center, Jackson; Department of Neurology (P.P.), University of North Carolina at Chapel Hill; Department of Neurology (D.S.K.), Mayo Clinic, Rochester, MN; Stroke Branch (R.F.G.), National Institute of Neurological Disorders and Stroke Intramural Research Program, Bethesda, MD; and Department of Epidemiology and Biostatistics (H.C.), Michigan State University, East Lansing.
Jennifer A DealFrom the The Memory Impairment and Neurodegenerative Dementia (MIND) Center (S.S., X.Z., K.J.S., C.B., J.H., B.G.W., M.E.G., T.H.M.), University of Mississippi Medical Center, Jackson; Department of Epidemiology (J.A.D., A.R.S.), Johns Hopkins University Bloomberg School of Public Health; Department of Psychiatry and Behavioral Sciences (V.K.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology (A.L.C.S.), and Department of Biostatistics, Epidemiology, and Informatics (A.L.C.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Radiology (C.R.J., R.I.R.), Mayo Clinic, Rochester, MN; Department of Neurology (J.H.), University of Mississippi Medical Center, Jackson; Department of Neurology (P.P.), University of North Carolina at Chapel Hill; Department of Neurology (D.S.K.), Mayo Clinic, Rochester, MN; Stroke Branch (R.F.G.), National Institute of Neurological Disorders and Stroke Intramural Research Program, Bethesda, MD; and Department of Epidemiology and Biostatistics (H.C.), Michigan State University, East Lansing.ORCID 0000-0002-6985-048X
A Richey SharrettFrom the The Memory Impairment and Neurodegenerative Dementia (MIND) Center (S.S., X.Z., K.J.S., C.B., J.H., B.G.W., M.E.G., T.H.M.), University of Mississippi Medical Center, Jackson; Department of Epidemiology (J.A.D., A.R.S.), Johns Hopkins University Bloomberg School of Public Health; Department of Psychiatry and Behavioral Sciences (V.K.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology (A.L.C.S.), and Department of Biostatistics, Epidemiology, and Informatics (A.L.C.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Radiology (C.R.J., R.I.R.), Mayo Clinic, Rochester, MN; Department of Neurology (J.H.), University of Mississippi Medical Center, Jackson; Department of Neurology (P.P.), University of North Carolina at Chapel Hill; Department of Neurology (D.S.K.), Mayo Clinic, Rochester, MN; Stroke Branch (R.F.G.), National Institute of Neurological Disorders and Stroke Intramural Research Program, Bethesda, MD; and Department of Epidemiology and Biostatistics (H.C.), Michigan State University, East Lansing.
Vidyulata KamathFrom the The Memory Impairment and Neurodegenerative Dementia (MIND) Center (S.S., X.Z., K.J.S., C.B., J.H., B.G.W., M.E.G., T.H.M.), University of Mississippi Medical Center, Jackson; Department of Epidemiology (J.A.D., A.R.S.), Johns Hopkins University Bloomberg School of Public Health; Department of Psychiatry and Behavioral Sciences (V.K.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology (A.L.C.S.), and Department of Biostatistics, Epidemiology, and Informatics (A.L.C.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Radiology (C.R.J., R.I.R.), Mayo Clinic, Rochester, MN; Department of Neurology (J.H.), University of Mississippi Medical Center, Jackson; Department of Neurology (P.P.), University of North Carolina at Chapel Hill; Department of Neurology (D.S.K.), Mayo Clinic, Rochester, MN; Stroke Branch (R.F.G.), National Institute of Neurological Disorders and Stroke Intramural Research Program, Bethesda, MD; and Department of Epidemiology and Biostatistics (H.C.), Michigan State University, East Lansing.
Andrea L C SchneiderFrom the The Memory Impairment and Neurodegenerative Dementia (MIND) Center (S.S., X.Z., K.J.S., C.B., J.H., B.G.W., M.E.G., T.H.M.), University of Mississippi Medical Center, Jackson; Department of Epidemiology (J.A.D., A.R.S.), Johns Hopkins University Bloomberg School of Public Health; Department of Psychiatry and Behavioral Sciences (V.K.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology (A.L.C.S.), and Department of Biostatistics, Epidemiology, and Informatics (A.L.C.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Radiology (C.R.J., R.I.R.), Mayo Clinic, Rochester, MN; Department of Neurology (J.H.), University of Mississippi Medical Center, Jackson; Department of Neurology (P.P.), University of North Carolina at Chapel Hill; Department of Neurology (D.S.K.), Mayo Clinic, Rochester, MN; Stroke Branch (R.F.G.), National Institute of Neurological Disorders and Stroke Intramural Research Program, Bethesda, MD; and Department of Epidemiology and Biostatistics (H.C.), Michigan State University, East Lansing.
Clifford R JackFrom the The Memory Impairment and Neurodegenerative Dementia (MIND) Center (S.S., X.Z., K.J.S., C.B., J.H., B.G.W., M.E.G., T.H.M.), University of Mississippi Medical Center, Jackson; Department of Epidemiology (J.A.D., A.R.S.), Johns Hopkins University Bloomberg School of Public Health; Department of Psychiatry and Behavioral Sciences (V.K.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology (A.L.C.S.), and Department of Biostatistics, Epidemiology, and Informatics (A.L.C.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Radiology (C.R.J., R.I.R.), Mayo Clinic, Rochester, MN; Department of Neurology (J.H.), University of Mississippi Medical Center, Jackson; Department of Neurology (P.P.), University of North Carolina at Chapel Hill; Department of Neurology (D.S.K.), Mayo Clinic, Rochester, MN; Stroke Branch (R.F.G.), National Institute of Neurological Disorders and Stroke Intramural Research Program, Bethesda, MD; and Department of Epidemiology and Biostatistics (H.C.), Michigan State University, East Lansing.ORCID 0000-0001-7916-622X
Juebin HuangFrom the The Memory Impairment and Neurodegenerative Dementia (MIND) Center (S.S., X.Z., K.J.S., C.B., J.H., B.G.W., M.E.G., T.H.M.), University of Mississippi Medical Center, Jackson; Department of Epidemiology (J.A.D., A.R.S.), Johns Hopkins University Bloomberg School of Public Health; Department of Psychiatry and Behavioral Sciences (V.K.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology (A.L.C.S.), and Department of Biostatistics, Epidemiology, and Informatics (A.L.C.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Radiology (C.R.J., R.I.R.), Mayo Clinic, Rochester, MN; Department of Neurology (J.H.), University of Mississippi Medical Center, Jackson; Department of Neurology (P.P.), University of North Carolina at Chapel Hill; Department of Neurology (D.S.K.), Mayo Clinic, Rochester, MN; Stroke Branch (R.F.G.), National Institute of Neurological Disorders and Stroke Intramural Research Program, Bethesda, MD; and Department of Epidemiology and Biostatistics (H.C.), Michigan State University, East Lansing.
Priya PaltaFrom the The Memory Impairment and Neurodegenerative Dementia (MIND) Center (S.S., X.Z., K.J.S., C.B., J.H., B.G.W., M.E.G., T.H.M.), University of Mississippi Medical Center, Jackson; Department of Epidemiology (J.A.D., A.R.S.), Johns Hopkins University Bloomberg School of Public Health; Department of Psychiatry and Behavioral Sciences (V.K.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology (A.L.C.S.), and Department of Biostatistics, Epidemiology, and Informatics (A.L.C.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Radiology (C.R.J., R.I.R.), Mayo Clinic, Rochester, MN; Department of Neurology (J.H.), University of Mississippi Medical Center, Jackson; Department of Neurology (P.P.), University of North Carolina at Chapel Hill; Department of Neurology (D.S.K.), Mayo Clinic, Rochester, MN; Stroke Branch (R.F.G.), National Institute of Neurological Disorders and Stroke Intramural Research Program, Bethesda, MD; and Department of Epidemiology and Biostatistics (H.C.), Michigan State University, East Lansing.
Robert I ReidFrom the The Memory Impairment and Neurodegenerative Dementia (MIND) Center (S.S., X.Z., K.J.S., C.B., J.H., B.G.W., M.E.G., T.H.M.), University of Mississippi Medical Center, Jackson; Department of Epidemiology (J.A.D., A.R.S.), Johns Hopkins University Bloomberg School of Public Health; Department of Psychiatry and Behavioral Sciences (V.K.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology (A.L.C.S.), and Department of Biostatistics, Epidemiology, and Informatics (A.L.C.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Radiology (C.R.J., R.I.R.), Mayo Clinic, Rochester, MN; Department of Neurology (J.H.), University of Mississippi Medical Center, Jackson; Department of Neurology (P.P.), University of North Carolina at Chapel Hill; Department of Neurology (D.S.K.), Mayo Clinic, Rochester, MN; Stroke Branch (R.F.G.), National Institute of Neurological Disorders and Stroke Intramural Research Program, Bethesda, MD; and Department of Epidemiology and Biostatistics (H.C.), Michigan State University, East Lansing.
David S KnopmanFrom the The Memory Impairment and Neurodegenerative Dementia (MIND) Center (S.S., X.Z., K.J.S., C.B., J.H., B.G.W., M.E.G., T.H.M.), University of Mississippi Medical Center, Jackson; Department of Epidemiology (J.A.D., A.R.S.), Johns Hopkins University Bloomberg School of Public Health; Department of Psychiatry and Behavioral Sciences (V.K.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology (A.L.C.S.), and Department of Biostatistics, Epidemiology, and Informatics (A.L.C.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Radiology (C.R.J., R.I.R.), Mayo Clinic, Rochester, MN; Department of Neurology (J.H.), University of Mississippi Medical Center, Jackson; Department of Neurology (P.P.), University of North Carolina at Chapel Hill; Department of Neurology (D.S.K.), Mayo Clinic, Rochester, MN; Stroke Branch (R.F.G.), National Institute of Neurological Disorders and Stroke Intramural Research Program, Bethesda, MD; and Department of Epidemiology and Biostatistics (H.C.), Michigan State University, East Lansing.
Rebecca F GottesmanFrom the The Memory Impairment and Neurodegenerative Dementia (MIND) Center (S.S., X.Z., K.J.S., C.B., J.H., B.G.W., M.E.G., T.H.M.), University of Mississippi Medical Center, Jackson; Department of Epidemiology (J.A.D., A.R.S.), Johns Hopkins University Bloomberg School of Public Health; Department of Psychiatry and Behavioral Sciences (V.K.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology (A.L.C.S.), and Department of Biostatistics, Epidemiology, and Informatics (A.L.C.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Radiology (C.R.J., R.I.R.), Mayo Clinic, Rochester, MN; Department of Neurology (J.H.), University of Mississippi Medical Center, Jackson; Department of Neurology (P.P.), University of North Carolina at Chapel Hill; Department of Neurology (D.S.K.), Mayo Clinic, Rochester, MN; Stroke Branch (R.F.G.), National Institute of Neurological Disorders and Stroke Intramural Research Program, Bethesda, MD; and Department of Epidemiology and Biostatistics (H.C.), Michigan State University, East Lansing.
Honglei ChenFrom the The Memory Impairment and Neurodegenerative Dementia (MIND) Center (S.S., X.Z., K.J.S., C.B., J.H., B.G.W., M.E.G., T.H.M.), University of Mississippi Medical Center, Jackson; Department of Epidemiology (J.A.D., A.R.S.), Johns Hopkins University Bloomberg School of Public Health; Department of Psychiatry and Behavioral Sciences (V.K.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology (A.L.C.S.), and Department of Biostatistics, Epidemiology, and Informatics (A.L.C.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Radiology (C.R.J., R.I.R.), Mayo Clinic, Rochester, MN; Department of Neurology (J.H.), University of Mississippi Medical Center, Jackson; Department of Neurology (P.P.), University of North Carolina at Chapel Hill; Department of Neurology (D.S.K.), Mayo Clinic, Rochester, MN; Stroke Branch (R.F.G.), National Institute of Neurological Disorders and Stroke Intramural Research Program, Bethesda, MD; and Department of Epidemiology and Biostatistics (H.C.), Michigan State University, East Lansing.
B Gwen WindhamFrom the The Memory Impairment and Neurodegenerative Dementia (MIND) Center (S.S., X.Z., K.J.S., C.B., J.H., B.G.W., M.E.G., T.H.M.), University of Mississippi Medical Center, Jackson; Department of Epidemiology (J.A.D., A.R.S.), Johns Hopkins University Bloomberg School of Public Health; Department of Psychiatry and Behavioral Sciences (V.K.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology (A.L.C.S.), and Department of Biostatistics, Epidemiology, and Informatics (A.L.C.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Radiology (C.R.J., R.I.R.), Mayo Clinic, Rochester, MN; Department of Neurology (J.H.), University of Mississippi Medical Center, Jackson; Department of Neurology (P.P.), University of North Carolina at Chapel Hill; Department of Neurology (D.S.K.), Mayo Clinic, Rochester, MN; Stroke Branch (R.F.G.), National Institute of Neurological Disorders and Stroke Intramural Research Program, Bethesda, MD; and Department of Epidemiology and Biostatistics (H.C.), Michigan State University, East Lansing.
Michael E GriswoldFrom the The Memory Impairment and Neurodegenerative Dementia (MIND) Center (S.S., X.Z., K.J.S., C.B., J.H., B.G.W., M.E.G., T.H.M.), University of Mississippi Medical Center, Jackson; Department of Epidemiology (J.A.D., A.R.S.), Johns Hopkins University Bloomberg School of Public Health; Department of Psychiatry and Behavioral Sciences (V.K.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology (A.L.C.S.), and Department of Biostatistics, Epidemiology, and Informatics (A.L.C.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Radiology (C.R.J., R.I.R.), Mayo Clinic, Rochester, MN; Department of Neurology (J.H.), University of Mississippi Medical Center, Jackson; Department of Neurology (P.P.), University of North Carolina at Chapel Hill; Department of Neurology (D.S.K.), Mayo Clinic, Rochester, MN; Stroke Branch (R.F.G.), National Institute of Neurological Disorders and Stroke Intramural Research Program, Bethesda, MD; and Department of Epidemiology and Biostatistics (H.C.), Michigan State University, East Lansing.
Thomas H MosleyFrom the The Memory Impairment and Neurodegenerative Dementia (MIND) Center (S.S., X.Z., K.J.S., C.B., J.H., B.G.W., M.E.G., T.H.M.), University of Mississippi Medical Center, Jackson; Department of Epidemiology (J.A.D., A.R.S.), Johns Hopkins University Bloomberg School of Public Health; Department of Psychiatry and Behavioral Sciences (V.K.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology (A.L.C.S.), and Department of Biostatistics, Epidemiology, and Informatics (A.L.C.S.), University of Pennsylvania Perelman School of Medicine, Philadelphia; Department of Radiology (C.R.J., R.I.R.), Mayo Clinic, Rochester, MN; Department of Neurology (J.H.), University of Mississippi Medical Center, Jackson; Department of Neurology (P.P.), University of North Carolina at Chapel Hill; Department of Neurology (D.S.K.), Mayo Clinic, Rochester, MN; Stroke Branch (R.F.G.), National Institute of Neurological Disorders and Stroke Intramural Research Program, Bethesda, MD; and Department of Epidemiology and Biostatistics (H.C.), Michigan State University, East Lansing.
University of North Carolina at Chapel Hill · US

Funding

ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5U01HL096917 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOSLEY, THOMAS H · 2010 to 2018
$11.9M
Stroke, Cognition and Neuroepidemiology SectionZIANS009435 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI GOTTESMAN, REBECCA F · 2022 to 2025
$8.2M
Prospective studies on Parkinson's diseaseZIAES101986 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI CHEN, HONGLEI · 2009 to 2016
$7.9M
ARIC Neurocognitive Study (ARIC-NCS) Renewal UNC 4 of 5U01HL096899 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J · 2010 to 2018
$7.5M
ARIC Neurocognitive Study (ARIC-NCS)U01HL096902 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2010 to 2018
$7.4M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 4 of 5U01HL096814 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUGHES, TIMOTHY M., WAGENKNECHT, LYNNE E · 2010 to 2018
$6.5M
The ARIC and Neurocognitive Longitudinal StudyR01HL070825 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI MOSLEY, THOMAS H · 2002 to 2004
$5.1M
Advanced MR Imaging of Olfactory Impairment in Prodromal Alzheimer's DiseaseR01AG064093 · NIA · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI BAKKER, ARNOLD, HUA, JUN · 2020 to 2024
$3.9M
Imaging small blood and lymphatic vessel abnormalities of the olfactory system in schizophreniaR01NS108452 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI HUA, JUN, KAMATH, VIDYULATA · 2018 to 2022
$3.2M
Poor sense of smell and the health of older adultsR01AG071517 · NIA · MICHIGAN STATE UNIVERSITY · PI HONGLEI CHEN · 2022 to 2026
$2.7M
Establishing Mechanisms Between Traumatic Brain Injury and Dementia Using Epidemiology, Clinical Studies, Blood-Based Biomarkers, and Neuroimaging BiomarkersK23NS123340 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Andrea Lauren Christman Schneider · 2022 to 2026
$1.1M
Intramural NIH HHS ZIA ES101986NHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005INHLBI NIH HHS R01 HL070825NHLBI NIH HHS U01 HL096812NHLBI NIH HHS U01 HL096814NHLBI NIH HHS U01 HL096899NHLBI NIH HHS U01 HL096902NHLBI NIH HHS U01 HL096917NIA NIH HHS K01 AG054693NIA NIH HHS R00 AG052830NIA NIH HHS R01 AG064093NIA NIH HHS R01 AG071517NINDS NIH HHS K23 NS123340NINDS NIH HHS R01 NS108452
6 · The paper itself

Abstract

BACKGROUND AND

objectivesResearch on olfaction and brain neuropathology may help understand brain regions associated with normal olfaction and dementia pathophysiology. To identify early regional brain structures affected in poor olfaction, we examined cross-sectional associations of microstructural integrity of the brain with olfaction in the Atherosclerosis Risk in Communities Neurocognitive Study.

methodsParticipants were selected from a prospective cohort study of community-dwelling adults; selection criteria included the following: evidence of cognitive impairment, participation in a previous MRI study, and a random sample of cognitively normal participants. Microstructural integrity was measured by 2 diffusion tensor imaging (DTI) measures, fractional anisotropy (FA) and mean diffusivity (MD), and olfaction by a 12-item odor identification test at the same visit. Higher FA and MD values indicate better and worse microstructural integrity, respectively, and higher odor identification scores indicate better olfaction. We used brain region-specific linear regression models to examine associations between DTI measures and olfaction, adjusting for potential confounders.

resultsAmong 1,418 participants (mean age 76 ± 5 years, 41% male, 21% Black race, 59% with normal cognition), the mean olfaction score was 9 ± 2.3. Relevant to olfaction, higher MD in the medial temporal lobe (MTL) regions, namely the hippocampus (β -0.79 [95% CI -0.94 to -0.65] units lower olfaction score per 1 SD higher MD), amygdala, entorhinal area, and some white matter (WM) tracts connecting to these regions, was associated with olfaction. We also observed associations with MD and WM FA in multiple atlas regions that were not previously implicated in olfaction. The associations between MD and olfaction were particularly stronger in the MTL regions among individuals with mild cognitive impairment (MCI) compared with those with normal cognition (e.g., β DISCUSSION: Neuronal microstructural integrity in multiple brain regions, particularly the MTL (the regions known to be affected in early Alzheimer disease), is associated with odor identification ability. Differential associations in the MTL regions among cognitively normal individuals compared with those with MCI may reflect the earlier vs later effects of the dementia pathogenesis. It is likely that some of the associated regions may not have any functional relevance to olfaction.

Indexed as

AtherosclerosisDementiaWhite MatterAdultAgedAged, 80 and overAnisotropyBrainCross-Sectional StudiesDiffusion Tensor ImagingFemaleHumansIndependent LivingMaleProspective StudiesSmell

Identifiers

PMID37541841
PMCPMC10558165
OpenAlexW4385568525

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