ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023
Effects of Adult Age and Functioning of the Locus Coeruleus Norepinephrinergic System on Reward-Based Learning.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Brain structure in the cingulate cortex and locus coeruleus in late life is associated with engagement in complex mental activities across the life span.Neurobiology of aging · 2026Article
- Exercise-induced neuropeptidergic and neurochemical neuroadaptation in stress regulation and emotional disorders.Acta neurologica Belgica · 2026Review
- Age-Related Changes in Curiosity: The Influence of Locus Coeruleus on Information-Seeking Behavior.bioRxiv : the preprint server for biology · 2025Article
- Understanding the cognitive factors which contribute to individual differences in financial capacity in aging.Scientific reports · 2025Article
- Locus coeruleus contrast and diffusivity metrics differentially relate to age and memory performance.Scientific reports · 2024Article
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Authors and funding
4 authors.
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Abstract
Age-related impairments in value representations and updating during decision-making and reward-based learning are often related to age-related attenuation in the catecholamine system such as dopamine (DA) and norepinephrine (NE). However, it is unclear to what extent age-related declines in NE functioning in humans affect reward-based decision-making. We conducted a probabilistic decision-making task and applied a Q-learning model to investigate participants' anticipatory values and value sensitivities. Task-related pupil dilations and locus coeruleus (LC) magnetic resonance imaging (MRI) contrast, which served as a potential window of the LC-NE functions, were assessed in younger and older adults. Results showed that in both choice and feedback phases, younger adults' (
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