Evidence map›Paper›PMID 37541670›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

Enantioselective S

En Li, Kai Tang, Zhuhui Ren, Xiaoyun Liao, Qianchen Liu, Yong Huang, Jiean Chen

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Enantioselective SAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

En LiPingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, 518118, China.
Kai TangPingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, 518118, China.
Zhuhui RenPingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, 518118, China.
Xiaoyun LiaoPingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, 518118, China.
Qianchen LiuPingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, 518118, China.
Yong HuangDepartment of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, 999077, China.
Jiean ChenPingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, 518118, China.ORCID https://orcid.org/0000-0003-0703-5831

Funding

Hong Kong RGC 16300320Hong Kong RGC 16302122Hong Kong RGC 16309021National Natural Science Foundation of China 21825101Shenzhen Science and Technology Innovation Commission KCXFZ20201221173404013Shenzhen Science and Technology Innovation Commission SGDX2019081623241924
6 · The paper itself

Abstract

The functionalization of the β-carbon of enals with electrophiles is a signature umpolung reactivity of N-heterocyclic carbene (NHC) derived homoenolates. However, only a limited number of electrophiles are shown to be compatible, with most of them being π-electrophiles. In this study, the successful enantioselective β-alkylation of homoenolates is reported using C

Indexed as

enantioselective β-alkylationhomoenolateN-heterocyclic carbeneSN2 strategy

Identifiers

PMID37541670
PMCPMC10582416

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.