Evidence map›Paper›PMID 37541432›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2023

Elucidation of Protonation Cooperativity of a STING-Activating Polymer.

Maggie Wang, Zachary T Bennett, Parnavi Singh, Qiang Feng, Jonathan Wilhelm, Gang Huang, Jinming Gao

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Maggie WangDepartment of Biomedical Engineering, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Zachary T BennettDepartment of Biomedical Engineering, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Parnavi SinghDepartment of Biomedical Engineering, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Qiang FengDepartment of Biomedical Engineering, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Jonathan WilhelmDepartment of Biomedical Engineering, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Gang HuangDepartment of Biomedical Engineering, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.ORCID https://orcid.org/0000-0001-6658-9557
Jinming GaoDepartment of Biomedical Engineering, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.ORCID https://orcid.org/0000-0003-0726-5098
The University of Texas Southwestern Medical Center · US

Funding

STING Activating Synthetic Nanovaccine for HPV-Induced CancersR01CA216839 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI GAO, JINMING · 2018 to 2022
$1.9M
Investigating TLR-agonist adjuvancy in STING-activating nanoparticle cancer vaccinesF31CA247152 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI BENNETT, ZACHARY · 2021 to 2023
$107k
NCI NIH HHS F31 CA247152NCI NIH HHS R01 CA216839NIH HHS F31CA247152NIH HHS R01CA216839
6 · The paper itself

Abstract

Stimuli-responsive nanomaterials have the potential to improve the performance and overcome existing barriers of conventional nanotherapeutics. Molecular cooperativity design in stimuli-responsive nanomedicine can amplify physiological signals, enabling a cooperative response for improved diagnostic and therapeutic precision. Previously, this work reported an ultra-pH-sensitive polymer, PEG-b-PC7A, that possesses innate immune activating properties by binding to the stimulator of interferon genes (STING) through polyvalent phase condensation. This interaction enhances STING activation and synergizes with the endogenous STING ligand for robust cancer immunotherapy. Despite its successes in innate immune activation, the fundamental physicochemical and pH-responsive properties of PC7A require further investigation. Here, this study elucidates the protonation cooperativity driven by the phase transition of PC7A copolymer. The highly cooperative system displays an "all-or-nothing" proton distribution between highly charged unimer (all) and neutral micelle (nothing) states without gradually protonated intermediates. The binary protonation behavior is further illustrated in pH-precision-controlled release of a representative anticancer drug, β-lapachone, by PC7A micelles over a noncooperative PE5A polymer. Furthermore, the bimodal distribution of protons is represented by a high Hill coefficient (n

Indexed as

Antineoplastic AgentsMembrane ProteinsNanostructuresHydrogen-Ion ConcentrationMicellesPhase TransitionPolymersSTING ProteinAntineoplastic AgentsMembrane ProteinsMicellesPolymersSTING1 protein, humanSTING Proteinmolecular cooperativitynanomedicinenanoscale self-assemblyultra-pH-sensitive micelles

Identifiers

PMID37541432
PMCPMC10838353
OpenAlexW4385567521

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.