Evidence map›Paper›PMID 37541424›Full record

ArticleThe Journal of pediatrics2023

Growth Velocities Across Distinct Early Life Windows and Child Cognition: Insights from a Contemporary US Cohort.

Yi Ying Ong, Sheryl L Rifas-Shiman, Wei Perng, Mandy B Belfort, Evelyn Law, Marie-France Hivert, Emily Oken, Henning Tiemeier, Izzuddin M Aris

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
4.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Yi Ying OngDepartment of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: yiyingong@hsph.harvard.edu.
Sheryl L Rifas-ShimanDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA.
Wei PerngDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO; Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO.
Mandy B BelfortDepartment of Pediatric Newborn Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Evelyn LawDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore.
Marie-France HivertDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA; Diabetes Unit, Massachusetts General Hospital, Boston, MA.
Emily OkenDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA.
Henning TiemeierDepartment of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA.
Izzuddin M ArisDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA.
Harvard University · USAgency for Science, Technology and Research · SGBrigham and Women's Hospital · USColorado School of Public Health · US

Funding

Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methodsUH3OD023286 · OD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2018 to 2022
$11.7M
Maintain and Enrich Resource Infrastructure for Project Viva: a pre-birth cohort with follow up into adolescenceR24ES030894 · NIEHS · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2020 to 2024
$2.0M
NICHD NIH HHS R01 HD034568NIEHS NIH HHS R24 ES030894NIH HHS UH3 OD023286
6 · The paper itself

Abstract

objectiveTo evaluate the relative importance of overall and period-specific postnatal growth and their interaction with fetal growth on cognition in a generally well-nourished population. STUDY

designWe included 1052 children from Project Viva, a prospective cohort in Boston, Massachusetts. Using linear spline mixed-effects models, we modeled length/height and body mass index (BMI) trajectories from birth to 7 years and estimated standardized overall (0-7 years) and period-specific growth velocities ie, early infancy (0-4 months), late infancy (4-15 months), toddlerhood (15-37 months), and early childhood (37-84 months). We investigated associations of growth velocities as well as their interactions with birthweight-for-gestational age on mid-childhood (mean age: 7.9 years) IQ, visual memory and learning, and visual motor ability.

resultsGreater overall height velocity was associated with modestly higher design memory score, (adjusted β [95% CI] 0.19 [-0.01,0.38] P = .057])points per SD increase but lower verbal IQ (-0.88 [-1.76,0.00] P = .051). Greater early infancy height velocity was associated with higher visual motor score (1.92 [0.67,3.18]). Greater overall BMI velocity was associated with lower verbal IQ (-0.71 [-1.52,0.11] P = .090). Greater late infancy BMI velocity was associated with lower verbal IQ (-1.21 [-2.07,-0.34]), design memory score (-0.22 [-0.42,-0.03)], but higher picture memory score (0.22 [0.01,0.43]). Greater early infancy height velocity (-1.5 SD vs 1.5 SD) was associated with higher nonverbal IQ (margins [95% CI] 102.6 [98.9106.3] vs 108.2 [104.9111.6]) among small-for-gestational age infants (P-interaction = 0.04).

conclusionsAmong generally well-nourished children, there might not be clear cognitive gains with faster linear growth except for those with lower birthweight-for-gestational age, revealing the potential importance of early infancy compensatory growth.

Indexed as

Child DevelopmentCognitionBirth WeightBody Mass IndexChildChild, PreschoolHumansInfantLinear ModelsProspective Studiesadiposityearly infancygrowth trajectoryheightiQsmall-for-gestational agevisual motor ability

Identifiers

PMID37541424
PMCPMC10837309
OpenAlexW4385481666

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.