ArticleCurrent biology : CB2023
Widespread coding of navigational variables in prefrontal cortex.
Article in Current biology : CB, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Distributed neural codes of the 3D position in the marmoset frontal cortex and hippocampus.Nature communications · 2026Article
- Mid-superior temporal sulcus encodes spatial context and behavioral state in freely moving macaques.bioRxiv : the preprint server for biology · 2026Article
- Primate neuroethology: a new synthesis.Trends in cognitive sciences · 2026Review
- Neural geometry in the human hippocampus enables generalization across spatial position and gaze.ArXiv · 2026Article
- Article
- Rethinking the centrality of brain areas in understanding functional organization.Nature neuroscience · 2026Review
- How distributed is the brain-wide network that is recruited for cognition?Nature reviews. Neuroscience · 2026Review
- Change-of-mind neuroeconomic decision-making is modulated by LINC00473 in medial prefrontal cortex in a sex-dependent manner.Science advances · 2025Article
- Home-Cage Training for Non-Human Primates: An Opportunity to Reduce Stress and Study Natural Behavior in Neurophysiology Experiments.Animals : an open access journal from MDPI · 2025Review
- Building egocentric models of local space from retinal input.Current biology : CB · 2024Review
- Article
- Interactions between neural representations of the social and spatial environment.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- The big mixup: Neural representation during natural modes of primate visual behavior.Current opinion in neurobiology · 2024Review
- Encoding of 2D Self-Centered Plans and World-Centered Positions in the Rat Frontal Orienting Field.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- A Double Hit of Social and Economic Stress in Mice Precipitates Changes in Decision-Making Strategies.Biological psychiatry · 2024Article
- A-SOiD, an active-learning platform for expert-guided, data-efficient discovery of behavior.Nature methods · 2024Article
- Neural timescales reflect behavioral demands in freely moving rhesus macaques.Nature communications · 2024Article
- Hierarchical action encoding in prefrontal cortex of freely moving macaques.Cell reports · 2023Article
- Neural timescales reflect behavioral demands in freely moving rhesus macaques.bioRxiv : the preprint server for biology · 2023Article
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Abstract
To navigate effectively, we must represent information about our location in the environment. Traditional research highlights the role of the hippocampal complex in this process. Spurred by recent research highlighting the widespread cortical encoding of cognitive and motor variables previously thought to have localized function, we hypothesized that navigational variables would be likewise encoded widely, especially in the prefrontal cortex, which is associated with volitional behavior. We recorded neural activity from six prefrontal regions while macaques performed a foraging task in an open enclosure. In all regions, we found strong encoding of allocentric position, allocentric head direction, boundary distance, and linear and angular velocity. These encodings were not accounted for by distance, time to reward, or motor factors. The strength of coding of all variables increased along a ventral-to-dorsal gradient. Together, these results argue that encoding of navigational variables is not localized to the hippocampus and support the hypothesis that navigation is continuous with other forms of flexible cognition in the service of action.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.