Evidence map›Paper›PMID 37541197›Full record

ArticleCell2023

A widely distributed gene cluster compensates for uricase loss in hominids.

Yuanyuan Liu, J Bryce Jarman, Yen S Low, Hannah E Augustijn, Steven Huang, Haoqing Chen, Mary E DeFeo, Kazuma Sekiba, Bi-Huei Hou, Xiandong Meng and 9 more

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 79 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 1 pooled it
26.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 1 synthesis or guideline pooled it, 131 citations in OpenAlex.

  1. Pooled it
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  7. Article
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  14. Urate metabolism in the gut.Life metabolism · 2026
    Article
  15. Article
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  17. Article
  18. Article
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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 2 countries.

Yuanyuan LiuDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
J Bryce JarmanDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Yen S LowAtropos Health, Palo Alto, CA, USA.
Hannah E AugustijnBioinformatics Group, Wageningen University, Wageningen, the Netherlands; Institute of Biology, Leiden University, Leiden, the Netherlands.
Steven HuangDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Haoqing ChenDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Mary E DeFeoDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Kazuma SekibaDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Bi-Huei HouDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Xiandong MengChEM-H Institute, Stanford University, Stanford, CA 94305, USA.
Allison M WeakleyChEM-H Institute, Stanford University, Stanford, CA 94305, USA.
Ashley V CabreraChEM-H Institute, Stanford University, Stanford, CA 94305, USA.
Zhiwei ZhouDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Gilles van WezelInstitute of Biology, Leiden University, Leiden, the Netherlands; Netherlands Institute of Ecology, Wageningen, the Netherlands.
Marnix H MedemaBioinformatics Group, Wageningen University, Wageningen, the Netherlands; Institute of Biology, Leiden University, Leiden, the Netherlands.
Calyani GanesanDivision of Nephrology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Alan C PaoDivision of Nephrology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Urology, Stanford University School of Medicine, Stanford, CA 94305, USA; Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA.
Saurabh GombarDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Atropos Health, Palo Alto, CA, USA.
Dylan DoddDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: ddodd2@stanford.edu.
Stanford University · USLeiden University · NLStanford Health Care · USStanford Medicine · USUniversity of California, Berkeley · USVA Palo Alto Health Care System · US

Funding

Microbiota-based probiotics to treat inborn errors in metabolismR01AT011396 · NCCIH · STANFORD UNIVERSITY · PI Dylan Dodd · 2022 to 2026
$2.9M
Physiology of bacterial metabolism in the human gut microbiomeR35GM142873 · NIGMS · STANFORD UNIVERSITY · PI DODD, DYLAN · 2021 to 2025
$2.0M
Modulation of gut bacteria-derived host metabolitesK08DK110335 · NIDDK · STANFORD UNIVERSITY · PI DODD, DYLAN · 2018 to 2021
$573k
NCCIH NIH HHS R01 AT011396NIDDK NIH HHS K08 DK110335NIGMS NIH HHS R35 GM142873
6 · The paper itself

Abstract

Approximately 15% of US adults have circulating levels of uric acid above its solubility limit, which is causally linked to the disease gout. In most mammals, uric acid elimination is facilitated by the enzyme uricase. However, human uricase is a pseudogene, having been inactivated early in hominid evolution. Though it has long been known that uric acid is eliminated in the gut, the role of the gut microbiota in hyperuricemia has not been studied. Here, we identify a widely distributed bacterial gene cluster that encodes a pathway for uric acid degradation. Stable isotope tracing demonstrates that gut bacteria metabolize uric acid to xanthine or short chain fatty acids. Ablation of the microbiota in uricase-deficient mice causes severe hyperuricemia, and anaerobe-targeted antibiotics increase the risk of gout in humans. These data reveal a role for the gut microbiota in uric acid excretion and highlight the potential for microbiome-targeted therapeutics in hyperuricemia.

Indexed as

GoutHominidaeHyperuricemiaAdultAnimalsEvolution, MolecularHumansMammalsMiceUrate OxidaseUric AcidUrate OxidaseUric Acidgouthyperuricemiamicrobiomemicrobiotauric aciduricase

Identifiers

PMID37541197
PMCPMC10421625
OpenAlexW4385555239

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.