Evidence map›Paper›PMID 37540747›Full record

ArticleScience advances2023

Single-cell analysis of multiple invertible promoters reveals differential inversion rates as a strong determinant of bacterial population heterogeneity.

Freeman Lan, Jason Saba, Yili Qian, Tyler Ross, Robert Landick, Ophelia S Venturelli

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. A programmed reset mechanism primesScience advances · 2026
    Article
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  4. Review
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  7. Article
  8. Review
  9. Microbiome Single Cell Atlases Generated with a Commercial Instrument.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  10. Article
  11. Article
  12. Sequencing-based analysis of microbiomes.Nature reviews. Genetics · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Freeman LanDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53726, USA.ORCID 0000-0003-0465-6376
Jason SabaDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53726, USA.ORCID 0000-0001-7273-2970
Yili QianDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53726, USA.ORCID 0000-0002-1097-0401
Tyler RossDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53726, USA.ORCID 0000-0002-7128-152X
Robert LandickDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53726, USA.ORCID 0000-0002-5042-0383
Ophelia S VenturelliDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53726, USA.ORCID 0000-0003-2200-1963
University of Wisconsin–Madison · USUniversity of Wisconsin System · US

Funding

BIOTECHNOLOGY TRAINING PROGRAMT32GM008349 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI FOX, BRIAN G · 1989 to 2019
$22.5M
STRUCTURE/FUNCTION OF TRANSCRIPTION COMPLEX RNA HAIRPINSR01GM038660 · NIGMS · WASHINGTON UNIVERSITY · PI Robert Landick · 1992 to 2026
$12.2M
Biotechnology Training ProgramT32GM135066 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI SCOTT M. COYLE, BRIAN G FOX · 2020 to 2026
$7.0M
Elucidating the molecular and ecological design principles of stability and assembly of the human gut microbiotaR35GM124774 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Ophelia Venturelli · 2017 to 2026
$2.9M
Elucidating ecological mechanisms for propagation of antibiotic resistance genes via massively parallelized single-cell sequencingR21AI156438 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI VENTURELLI, OPHELIA · 2021 to 2022
$427k
Single-cell elucidation of transcriptional regulatory mechanisms that govern cell surface variation of the human symbiotic bacteria BacteroidetesF31GM142153 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI SABA, JOHNSON JARGESE · 2022 to 2023
$69k
NIAID NIH HHS R21 AI156438NIGMS NIH HHS F31 GM142153NIGMS NIH HHS R01 GM038660NIGMS NIH HHS R35 GM124774NIGMS NIH HHS T32 GM008349NIGMS NIH HHS T32 GM135066
6 · The paper itself

Abstract

Population heterogeneity can promote bacterial fitness in response to unpredictable environmental conditions. A major mechanism of phenotypic variability in the human gut symbiont

Indexed as

BacteriaChromosome InversionHumansPolysaccharidesPromoter Regions, GeneticSingle-Cell AnalysisPolysaccharides

Identifiers

PMID37540747
PMCPMC10403206
OpenAlexW4385565757

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.