Evidence map›Paper›PMID 37540625›Full record

ArticleJournal of the American Society for Mass Spectrometry2023

Customized Surface Design to Increase Throughput of Ambient Ionization Mass Spectrometry Lipidomics.

Christopher C Goudarzi, Ashley G Woolfork, Arjun Sengupta, Aalim M Weljie

Abstract read
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Christopher C GoudarziORCID 0009-0003-0108-4584
Ashley G Woolfork
Arjun Sengupta

Funding

Metabolomics of obstructive sleep apneaR01HL142981 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WELJIE, AALIM M · 2020 to 2023
$4.4M
Metabolic Reprogramming in Insomnia as a Function of Objective Sleep DurationR01NR018836 · NINR · UNIVERSITY OF PENNSYLVANIA · PI GEHRMAN, PHILIP RICHARD, WELJIE, AALIM M · 2020 to 2024
$3.4M
Balance of sleep and circadian metabolic switches in DrosophilaR01DK120757 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI SEHGAL, AMITA, WELJIE, AALIM M · 2019 to 2022
$2.1M
NHLBI NIH HHS R01 HL142981NIDDK NIH HHS R01 DK120757NINR NIH HHS R01 NR018836
6 · The paper itself

Abstract

Increased access to cheap and rapid mass spectrometry testing of biofluids is desirable for the analysis of disorders and diseases that may be linked to alterations in metabolite or lipid levels. The objective of this study is to establish an easily customized high-throughput workflow for the analysis of biological samples using desorption electrospray ionization-mass spectrometry (DESI-MS). The guiding principles of this workflow are the use of low-cost, open-source, and readily accessible materials with high-throughput and reproducibility. The design consists of 3 steps: (1) PARAFILM surface customization of size, shape, and depth of features on PARAFILM via 3D printed molds; (2) sample spotting via high-throughput robotics using the relatively inexpensive and open-source Opentrons platform to reduce variability and increase reliability of sample spotting; and (3) an open-source point-and-click graphical user interface (MSI.EAGLE) for data analysis via the R statistical language building on the

Indexed as

LipidomicsParaffinIonsReproducibility of ResultsSpectrometry, Mass, Electrospray IonizationIonsParaffin

Identifiers

PMID37540625
PMCPMC12765230

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.