Evidence map›Paper›PMID 37540395›Full record

ReviewCellular and molecular neurobiology2023

Primary Hypothyroidism and Alzheimer's Disease: A Tale of Two.

Faisal Holil AlAnazi, Hayder M Al-Kuraishy, Athanasios Alexiou, Marios Papadakis, Mohamed H Mazhar Ashour, Saud A Alnaaim, Omnya Elhussieny, Hebatallah M Saad, Gaber El-Saber Batiha

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular and molecular neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 45 citations in OpenAlex.

  1. TMetabolic brain disease · 2026
    Article
  2. Review
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  6. Alzheimer disease: Amyloid peptide controversies and challenges of anti-Aβ immunotherapy.The Journal of pharmacology and experimental therapeutics · 2025
    Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
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  15. Review
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  20. The role of autophagy in Graves disease: knowns and unknowns.Frontiers in cell and developmental biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 4 countries.

Faisal Holil AlAnazi *Department of Medicine, College of Medicine, Majmaah University, Majmaah, Saudi Arabia.
Hayder M Al-Kuraishy *Department of Pharmacology, Toxicology and Medicine, Medical Faculty, College of Medicine, Al-Mustansiriyah University, P.O. Box 14132, Baghdad, Iraq.
Athanasios AlexiouDepartment of Science and Engineering, Novel Global Community Educational Foundation, Hebersham, NSW, 2770, Australia.
Marios PapadakisDepartment of Surgery II, University Hospital Witten-Herdecke, University of Witten-Herdecke, Heusnerstrasse 40, 42283, Wuppertal, Germany. marios_papadakis@yahoo.gr.
Mohamed H Mazhar AshourGeneral & Pediatric Surgery, Faculty of Medicine, Tanta University, Tanta, Egypt.
Saud A AlnaaimClinical Neurosciences Department, College of Medicine, King Faisal University, Hofuf, Saudi Arabia.
Omnya ElhussienyDepartment of Histology and Cytology, Faculty of Veterinary Medicine, Matrouh University, Marsa Matruh, 51744, Egypt.ORCID http://orcid.org/0000-0001-6351-594X
Hebatallah M SaadDepartment of Pathology, Faculty of Veterinary Medicine, Matrouh University, Marsa Matruh, 51744, Egypt.ORCID http://orcid.org/0000-0001-9555-7300
Gaber El-Saber BatihaDepartment of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, 22511, Egypt.ORCID http://orcid.org/0000-0002-7817-425X
Egypt Nanotechnology Center · EGDamanhour University · EGKing Faisal University · SAMajmaah University · SAMustansiriyah University · IQTanta University · EGWitten/Herdecke University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypothyroidism (HPT) HPT could be a risk factor for the development and progression of Alzheimer's disease (AD). In addition, progressive neurodegeneration in AD may affect the metabolism of thyroid hormones (THs) in the brain causing local brain HPT. Hence, the present review aimed to clarify the potential association between HPT and AD. HPT promotes the progression of AD by inducing the production of amyloid beta (Aβ) and tau protein phosphorylation with the development of synaptic plasticity and memory dysfunction. Besides, the metabolism of THs is dysregulated in AD due to the accumulation of Aβ and tau protein phosphorylation leading to local brain HPT. Additionally, HPT can affect AD neuropathology through various mechanistic pathways including dysregulation of transthyretin, oxidative stress, ER stress, autophagy dysfunction mitochondrial dysfunction, and inhibition of brain-derived neurotrophic factor. Taken together there is a potential link between HPT and AD, as HPT adversely impacts AD neuropathology and the reverse is also true.

Indexed as

Alzheimer DiseaseHypothyroidismAmyloid beta-PeptidesBrainHumanstau ProteinsAmyloid beta-Peptidestau ProteinsAlzheimer’s diseaseHypothyroidismMitochondrial dysfunctionOxidative stressThyroid-stimulating hormone

Identifiers

PMID37540395
PMCPMC10477255
OpenAlexW4385563946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.