Evidence map›Paper›PMID 37539852›Full record

ArticlePediatric pulmonology2023

Impact of intrinsic and extrinsic risk factors on early-onset lung disease in cystic fibrosis.

Leslie Huang, HuiChuan J Lai, Jie Song, Zijie Zhao, Qiongshi Lu, Sangita G Murali, Donna M Brown, Elizabeth A Worthey, Philip M Farrell

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric pulmonology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Breastfeeding, growth, and lung disease in the first 3 years of life in children with cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2025
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Leslie HuangDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.ORCID 0000-0001-9778-8102
HuiChuan J LaiDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.ORCID 0000-0001-8084-3988
Jie SongDepartment of Statistics, University of Wisconsin College of Letters and Sciences, Madison, Wisconsin, USA.
Zijie ZhaoDepartment of Statistics, University of Wisconsin College of Letters and Sciences, Madison, Wisconsin, USA.
Qiongshi LuDepartment of Statistics, University of Wisconsin College of Letters and Sciences, Madison, Wisconsin, USA.
Sangita G MuraliDepartment of Nutritional Sciences, University of Wisconsin College of Agriculture and Life Sciences, Madison, Wisconsin, USA.
Donna M BrownDepartments of Pediatrics and Genetics, Center for Computational Genomics and Data Science at the UAB Marnix E. Heersink School of Medicine, Birmingham, Alabama, USA.
Elizabeth A WortheyDepartments of Pediatrics and Genetics, Center for Computational Genomics and Data Science at the UAB Marnix E. Heersink School of Medicine, Birmingham, Alabama, USA.
Philip M FarrellDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.ORCID 0000-0003-0036-7016
University of Wisconsin–Madison · USInstitut thématique Génétique, génomique et bioinformatique · FRUniversity of Wisconsin System · US

Funding

Newborn Screening, Malnutrition and Lung Disease in Children with Cystic FibrosisR01DK072126 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI LAI, HUICHUAN J · 2006 to 2015
$4.3M
Early Childhood Diet, Growth, Gut Microbiome And Lung Health in Cystic FibrosisR01DK109692 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI LAI, HUICHUAN J · 2016 to 2021
$3.8M
Early Childhood Diet, Growth, Gut Microbiome and Lung Health in Cystic FibrosisR56DK109692 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI LAI, HUICHUAN J · 2015 to 2015
$150k
NIDDK NIH HHS R01 DK072126NIDDK NIH HHS R01 DK109692NIDDK NIH HHS R56 DK109692
6 · The paper itself

Abstract

backgroundAlthough respiratory pathology is known to develop in young children with cystic fibrosis (CF), the determinants of early-onset lung disease have not been elucidated.

objectiveWe aimed to determine the impact of potential intrinsic and extrinsic risk factors during the first 3 years of life, testing the hypothesis that both contribute significantly to early-onset CF lung disease.

designWe studied 104 infants born during 2012-2017, diagnosed through newborn screening by age 3 months, and evaluated comprehensively to 36 months of age. Lung disease manifestations were quantified with a new scoring system known as CFELD for Cystic Fibrosis Early-onset Lung Disease. The variants in the cystic fibrosis transmembrane conductance regulator (CFTR) gene were determined and categorized. Whole genome sequencing was performed on each subject and the data transformed to polygenic risk scores (PRS) that aggregate variants associated with lung function. Extrinsic factors included socioeconomic status (SES) indicators and environmental experiences such as exposures to smoking, pets, and daycare.

resultsWe found by univariate analysis that CFTR genotype and genetic modifiers aggregated by the PRS method were significantly associated with early-onset CF lung disease. Ordinal logistic regression analysis demonstrated that high and stable SES (maternal education ≥community college, stable 2-parent home, and not receiving Medicaid) and better growth (weight-for-age and height-for-age z-scores) reduced risks, while exposure to smoking and daycare ≥20 h/week increased the risk of CFELD severity.

conclusionsExtrinsic, modifiable determinants are influential early and potentially as important as the intrinsic risk factors in the onset of CF lung disease.

Indexed as

Cystic FibrosisChildChild, PreschoolCystic Fibrosis Transmembrane Conductance RegulatorGenotypeHumansInfantInfant, NewbornLungRisk FactorsCystic Fibrosis Transmembrane Conductance Regulatorcystic fibrosisgrowthmaternal educationpolygenic risk scoresocioeconomic statuswhole genome sequencing

Identifiers

PMID37539852
PMCPMC10592256
OpenAlexW4385563700

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.