Evidence map›Paper›PMID 37539784›Full record

ArticleJournal of the American Geriatrics Society2023

In sickness and in health: Loneliness, depression, and the role of marital quality among spouses of persons with dementia.

Kristie Y Hsu, Irena Cenzer, Krista L Harrison, Christine S Ritchie, Linda Waite, Ashwin Kotwal

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Kristie Y HsuDivision of General Internal Medicine, University of California, San Francisco, California, USA.
Irena CenzerDivision of Geriatrics, University of California, San Francisco, California, USA.
Krista L HarrisonDivision of Geriatrics, University of California, San Francisco, California, USA.ORCID 0000-0001-5373-3011
Christine S RitchieMassachusetts General Hospital Division of Palliative Care and Geriatric Medicine and Harvard Medical School, Boston, Massachusetts, USA.
Linda WaiteDepartment of Sociology, University of Chicago, Chicago, Illinois, USA.
Ashwin KotwalDivision of Geriatrics, University of California, San Francisco, California, USA.ORCID 0000-0002-6137-8512
University of California, San Francisco · USHarvard University · USSan Francisco VA Medical Center · USUniversity of Chicago · US

Funding

VARC CoreP30AG044281 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Louise C. Walter · 2013 to 2026
$19.9M
Unnecessary and Harmful Medication Use in Older Adults with DementiaP01AG066605 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MELISSA Diane ALDRIDGE · 2020 to 2026
$17.7M
Loneliness and Social Isolation Among Older Adults with and without Alzheimer's Disease and Related Dementia in the Last Years of LifeK23AG065438 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KOTWAL, ASHWIN AJIT · 2020 to 2024
$809k
Palliative Care for People Living at Home with Advancing Dementia and Their CaregiversK01AG059831 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HARRISON, KRISTA LYN · 2019 to 2023
$720k
NIA NIH HHS K01 AG059831NIA NIH HHS K23 AG065438NIA NIH HHS L30 AG060590NIA NIH HHS P01 AG066605NIA NIH HHS P30 AG044281
6 · The paper itself

Abstract

backgroundOlder adults married to persons living with dementia (PLwD) may be at risk for loneliness and depression. We assessed the prevalence of loneliness and depressive symptoms among spouses of PLwD or cognitive impairment not dementia (CIND), and the role of marital quality in mediating these outcomes.

methodsWe used a US population-based sample of 4071 couples enrolled in the Health and Retirement Study (2014 and 2016). We included older adults married to PLwD (N = 227), married to persons with CIND (N = 885), or married to persons with no cognitive impairment (NCI) (N = 2959). We determined the prevalence of loneliness (UCLA 3-item scale), depressive symptoms (CESD-8 scale), and both, using multivariable logistic regression adjusting for sociodemographic and health-related characteristics. We then tested for interaction terms between marital quality (4-item scale) and degree of spousal cognitive impairment for each outcome of loneliness and depressive symptoms.

resultsThe sample was 55% women and on average 67-years-old (range: 50-97). After adjustment, spouses of persons with cognitive impairment were more likely to be lonely (NCI: 20%, CIND: 23%, PLwD: 29%; p = 0.04), depressed (NCI: 8%, CIND: 15%, PLwD: 14%; p < 0.01), and both (NCI: 4%, CIND: 9%, PLwD: 7%; p < 0.01). The association between cognition and loneliness, but not depression, differed by marital quality (interaction p-value = 0.03). Among couples with high marital quality, spousal cognitive impairment was associated with higher likelihood of loneliness (p < 0.05). In contrast, no association existed between spousal cognition and loneliness among couples with lower marital quality (p = 0.37).

conclusionsOne in six spouses of persons with CIND or more advanced disease (PLwD) experienced depressive symptoms, and loneliness among spouses of PLwD was experienced at a twofold rate. By identifying and managing both, and facilitating interventions that promote high-quality social connection, clinical teams might improve the lives of older couples facing dementia.

Indexed as

Cognitive DysfunctionDementiaAgedDepressionFemaleHumansLonelinessMaleSpousesdementiadepressionlonelinessspouse

Identifiers

PMID37539784
PMCPMC10838362
OpenAlexW4385564478

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.