Evidence map›Paper›PMID 37539495›Full record

ArticleAging cell2023

Early-life atomic-bomb irradiation accelerates immunological aging and elevates immune-related intracellular reactive oxygen species.

Tomonori Hayashi, Naohiro Kato, Keiko Furudoi, Ikue Hayashi, Seishi Kyoizumi, Kengo Yoshida, Yoichiro Kusunoki, Kyoji Furukawa, Misa Imaizumi, Ayumi Hida and 2 more

Open access · goldAbstract read
In one paragraph

Article in Aging cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Tomonori HayashiDepartment of Molecular Biosciences, Radiation Effects Research Foundation, Hiroshima, Japan.ORCID 0000-0001-7929-5355
Naohiro KatoDepartment of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan.
Keiko FurudoiBiosample Research Center, Radiation Effects Research Foundation, Hiroshima, Japan.
Ikue HayashiCentral Research Laboratory, Hiroshima University Faculty of Medicine Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Seishi KyoizumiDepartment of Molecular Biosciences, Radiation Effects Research Foundation, Hiroshima, Japan.
Kengo YoshidaDepartment of Molecular Biosciences, Radiation Effects Research Foundation, Hiroshima, Japan.
Yoichiro KusunokiDepartment of Molecular Biosciences, Radiation Effects Research Foundation, Hiroshima, Japan.
Kyoji FurukawaBiostatistics Center, Kurume University, Kurume, Japan.
Misa ImaizumiBiosample Research Center, Radiation Effects Research Foundation, Hiroshima, Japan.
Ayumi HidaDepartment of Nagasaki Clinical Studies, Radiation Effects Research Foundation, Nagasaki, Japan.
Osamu TanabeBiosample Research Center, Radiation Effects Research Foundation, Hiroshima, Japan.
Waka OhishiDepartment of Hiroshima Clinical Studies, Radiation Effects Research Foundation, Hiroshima, Japan.
Radiation Effects Research Foundation · JPHiroshima University · JPKurume University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reactive oxygen species (ROS) play an important role in immune responses; however, their excessive production and accumulation increases the risk of inflammation-related diseases. Although irradiation is known to accelerate immunological aging, the underlying mechanism is still unclear. To determine the possible involvement of ROS in this mechanism, we examined 10,023 samples obtained from 3752 atomic-bomb survivors in Hiroshima and Nagasaki, who participated in repeated biennial examinations from 2008 to 2016, for the effects of aging and radiation exposure on intracellular ROS (H

Indexed as

CD8-Positive T-LymphocytesNuclear WarfareAgingCD4-Positive T-LymphocytesHumansImmunologic MemoryReactive Oxygen SpeciesSurvivorsT-Lymphocyte SubsetsReactive Oxygen Speciesatomic bombcentral memoryeffector memoryimmunological agingnaïveradiationreactive oxygen speciesT cell

Identifiers

PMID37539495
PMCPMC10577552
OpenAlexW4385564355

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.