ArticleNature cardiovascular research2023
Blockade of IL-6 signaling alleviates atherosclerosis in
Open access · greenAbstract read
In one paragraph
Article in Nature cardiovascular research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
18.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Macrophage-associated kinase signaling in atherosclerosis - a systematic review.Cell communication and signaling : CCS · 2026Pooled it
- Modification of Breakfast Fat Composition Can Modulate Cytokine and Other Inflammatory Mediators in Women: A Randomized Crossover Trial.Nutrients · 2023Trial
- Impaired Glycolysis Leads to Defective Efferocytosis and Impaired Plaque Resolution inCirculation · 2026Article
- TET2 as a Context-Dependent Epigenetic Integrator in Clonal Hematopoiesis, Inflammation, Cancer, and Immunotherapy.Cell biochemistry and function · 2026Review
- Myeloid Cell-Specific Deletion of LGR4 Suppresses Atherosclerotic Lesion Formation.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- Review
- Prevalence and potential associations of the 2022 newly introduced monocyte value for diagnosis of chronic myelomonocytic leukemia in a general Austrian population.Wiener medizinische Wochenschrift (1946) · 2026Article
- Inhibition of DNA demethylation attenuates experimental necrotizing enterocolitis via suppression of TLR4-mediated inflammation.Research square · 2026Article
- Atherosclerotic Cardiovascular Disease and Cancer.Immunological reviews · 2026Review
- Inflammatory Signatures in MDS: The Missing Link Between Genetics, Microenvironment, and Therapy.Cells · 2026Review
- Transcriptomic Profiling of Adipose Tissues in Sujiang Pigs Reveals Candidate Genes Associated with Tissue-Specific Fat Deposition.Life (Basel, Switzerland) · 2026Article
- Clonal haematopoiesis and cardiovascular disease, defining risk, filling gaps, and framing the future.NPJ cardiovascular health · 2026Review
- TET2 loss enhances early response to inflammation in primitive and committed myeloid cells.Experimental hematology · 2026Article
- Novel and emerging therapeutic strategies for clonal hematopoiesis.Haematologica · 2026Review
- Clonal hematopoiesis is associated with future diseases and mortality.Chinese medical journal · 2026Article
- Clonal hematopoiesis in the pathogenesis of non-hematologic diseases with therapeutic potential.Cancer cell international · 2026Review
- Geroscience insights into difficult-to-treat rheumatoid arthritis: the role of unhealthy aging, comorbidity, and therapeutic complexity.GeroScience · 2026Review
- TET2 in epigenetic control of immune cells: Implications for inflammatory responses and age-related pathologies.The Journal of biological chemistry · 2026Review
- Interleukin-18 Inhibition Aggravates Atherosclerosis in Jak2JACC. Basic to translational science · 2026Article
- Common clonal hematopoiesis driver mutations have disparate effects on macrophage cytokines, clonal expansion, and atherogenesis.JCI insight · 2026Article
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 1 country.
Wenli LiuDivision of Molecular Medicine, Department of Medicine, Columbia University, New York, NY, USA.ORCID 0000-0002-1981-611X
Mustafa YalcinkayaDivision of Molecular Medicine, Department of Medicine, Columbia University, New York, NY, USA.
Inés Fernández MaestreHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Malgorzata OlszewskaDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Patrick B AmpomahNovartis Institutes for Biomedical Research, Cambridge, MA, USA.
J Brett HeimlichDivision of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Ranran WangDivision of Molecular Medicine, Department of Medicine, Columbia University, New York, NY, USA.
Pablo Sánchez VelaHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-9286-8290
Tong XiaoDivision of Molecular Medicine, Department of Medicine, Columbia University, New York, NY, USA.ORCID 0000-0003-1462-4650
Alexander G BickDivision of Genomic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0001-5824-9595
Ross LevineHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-7884-1905
Eirini P PapapetrouDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Peter LibbyDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-1502-502X
Ira TabasDivision of Molecular Medicine, Department of Medicine, Columbia University, New York, NY, USA.
Nan WangDivision of Molecular Medicine, Department of Medicine, Columbia University, New York, NY, USA.ORCID 0000-0001-9976-0859
Alan R TallDivision of Molecular Medicine, Department of Medicine, Columbia University, New York, NY, USA.ORCID 0000-0002-7708-2417
Columbia University · USHanalei Watershed Hui · USMemorial Sloan Kettering Cancer Center · USIcahn School of Medicine at Mount Sinai · USVanderbilt University Medical Center · USBrigham and Women's Hospital · USNovartis (United States) · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MA Mechanistic and Translational Research Program Linking Impaired Resolution, Defective Efferocytosis, and Clonal Hematopoiesis to the Formation of Clinically Dangerous Atherosclerotic PlaquesR35HL145228 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI TABAS, IRA A · 2019 to 2025
$6.8MJAK2V617F, clonal hematopoiesis and atherosclerosisR01HL148071 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI NAN WANG · 2019 to 2026
$4.0MClonal hematopoiesis, inflammasomes and atherosclerosisR01HL155431 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ALAN richard TALL · 2021 to 2026
$3.7MMechanisms and Modulation of Accelerated Atherosclerosis in Clonal HematopoiesisR01HL163099 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2022 to 2025
$2.6MHDL, platelet progenitors, atherosclerosis and thrombosisR01HL118567 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WANG, NAN · 2014 to 2018
$2.0MNovel mechanisms of the thrombotic complications of atherosclerosisR01HL134892 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2019 to 2022
$1.7MNCI NIH HHS P30 CA008748NHLBI NIH HHS R01 HL118567NHLBI NIH HHS R01 HL134892NHLBI NIH HHS R01 HL148071NHLBI NIH HHS R01 HL155431NHLBI NIH HHS R01 HL163099NHLBI NIH HHS R35 HL145228
Abstract
Clonal hematopoiesis (CH) increases the risk of atherosclerotic cardiovascular disease possibly due to increased plaque inflammation. Human studies suggest that limitation of interleukin-6 (IL-6) signaling could be beneficial in people with large CH clones, particularly in
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