Evidence map›Paper›PMID 37538932›Full record

ArticleComputational molecular bioscience2023

Analysis of Differential Gene Expression and Core Canonical Pathways Involved in the Epithelial to Mesenchymal Transition of Triple Negative Breast Cancer Cells by Ingenuity Pathway Analysis.

Elizabeth Cagle, Brent Lake, Anasua Banerjee, Jazmine Cuffee, Narendra Banerjee, Darla Gilmartin, Makaiyah Liverman, Shennel Brown, Erik Armstrong, Santanu Bhattacharya and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational molecular bioscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Elizabeth CagleDepartment of Natural, Health and Human Sciences, Elizabeth City State University Campus of The University of North Carolina, Elizabeth, NC, USA.
Brent LakeDepartment of Natural, Health and Human Sciences, Elizabeth City State University Campus of The University of North Carolina, Elizabeth, NC, USA.
Anasua BanerjeeDepartment of Natural, Health and Human Sciences, Elizabeth City State University Campus of The University of North Carolina, Elizabeth, NC, USA.
Jazmine CuffeeDepartment of Natural, Health and Human Sciences, Elizabeth City State University Campus of The University of North Carolina, Elizabeth, NC, USA.
Narendra BanerjeeDepartment of Natural, Health and Human Sciences, Elizabeth City State University Campus of The University of North Carolina, Elizabeth, NC, USA.
Darla GilmartinDepartment of Natural, Health and Human Sciences, Elizabeth City State University Campus of The University of North Carolina, Elizabeth, NC, USA.
Makaiyah LivermanDepartment of Natural, Health and Human Sciences, Elizabeth City State University Campus of The University of North Carolina, Elizabeth, NC, USA.
Shennel BrownDepartment of Natural, Health and Human Sciences, Elizabeth City State University Campus of The University of North Carolina, Elizabeth, NC, USA.
Erik ArmstrongDepartment of Natural, Health and Human Sciences, Elizabeth City State University Campus of The University of North Carolina, Elizabeth, NC, USA.
Santanu BhattacharyaDepartment of Biochemistry and Molecular Biology, Mayo College of Medicine and Science, Jacksonville, FL, USA.
Somiranjan GhoshDepartments of Pediatrics and Child Health, College of Medicine, Howard University, Washington, DC, USA.
Tanmoy MandalDepartments of Pediatrics and Child Health, College of Medicine, Howard University, Washington, DC, USA.
Hirendra BanerjeeDepartment of Natural, Health and Human Sciences, Elizabeth City State University Campus of The University of North Carolina, Elizabeth, NC, USA.
Elizabeth City State University · USHoward University · USBioscience (China) · CNJacksonville College · US

Funding

Elizabeth City State University Minority Access to Research Careers (E-MARC) UndeT34GM100831 · NIGMS · ELIZABETH CITY STATE UNIVERSITY · PI BANERJEE, HIRENDRA N · 2012 to 2022
$1.9M
NIGMS NIH HHS T34 GM100831
6 · The paper itself

Abstract

Triple Negative Breast Cancer (TNBC) is a malignant form of cancer with very high mortality and morbidity. Epithelial to Mesenchymal Transition (EMT) is the most common pathophysiological change observed in cancer cells of epithelial origin that promotes metastasis, drug resistance and cancer stem cell formation. Since the information regarding differential gene expression in TNBC cells and cell signaling events leading to EMT is limited, this investigation was done by comparing transcriptomic data generated by RNA isolation and sequencing of a EMT model TNBC cell line in comparison to regular TNBC cells. RNA sequencing and Ingenuity Pathway Software Analysis (IPA) of the transcriptomic data revealed several upregulated and downregulated gene expressions along with novel core canonical pathways including Sirtuin signaling, Oxidative Phosphorylation and Mitochondrial dysfunction events involved in EMT changes of the TNBC cells.

Indexed as

Core Canonical PathwaysEpithelial to Mesenchymal TransitionTriple Negative Breast Cancer

Identifiers

PMID37538932
PMCPMC10398793
OpenAlexW4377080224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.