ArticleEClinicalMedicine2023
Clinical decision thresholds for surfactant administration in preterm infants: a systematic review and network meta-analysis.
Article in EClinicalMedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07176117 (Surfactant Prophylaxis in LAte Preterm to Early Term Infants Using a Supraglottic Airway Device to Help Improve Outcomes), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Surfactant Prophylaxis in LAte Preterm to Early Term Infants Using a Supraglottic Airway Device to Help Improve Outcomes
Who cites it
16 citing papers in PubMed, 19 citations in OpenAlex.
- Trial
- Surfactant therapy in neonatal care: advances, challenges, and practical considerations.European journal of pediatrics · 2026Review
- A three-factor nomogram predicts the use of invasive mechanical ventilation within 72 h in preterm infants.Frontiers in medicine · 2026Article
- Predicting Surfactant Need at Birth: Failed Validation of a Bedside Method Using Gastric Aspirates.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Less Invasive Surfactant Administration Versus Intubate-Surfactant-Extubate: Associated With Reduced Mechanical Ventilation in Extremely Preterm Infants.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Noninvasive Ventilation Strategies in Neonates.Indian pediatrics · 2025Review
- Changes in practice of less-invasive surfactant administration (LISA) in United Kingdom neonatal units.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Using a simplified Downes score to predict the receipt of surfactant in a highly resourced setting.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Pulse oximetry in pediatric care: Balancing advantages and limitations.World journal of clinical pediatrics · 2024Article
- Do Different Amounts of Exogenous Surfactant Differently Influence Cerebrovascular Instability in a Consecutive Group of Preterm Babies? Preliminary Results from a Single-Center Experience.Children (Basel, Switzerland) · 2024Article
- The Outcomes of Preterm Infants with Neonatal Respiratory Distress Syndrome Treated by Minimally Invasive Surfactant Therapy and Non-Invasive Ventilation.Biomedicines · 2024Article
- Gastric Fluid Metabolomics Predicting the Need for Surfactant Replacement Therapy in Very Preterm Infants Results of a Case-Control Study.Metabolites · 2024Article
- Prospective, non-blinded, randomized controlled trial on early administration of pulmonary surfactant guided by lung ultrasound scores in very preterm infants: study protocol.Frontiers in pediatrics · 2024Article
- Non-Invasive Ventilatory Support in Preterm Neonates in the Delivery Room and the Neonatal Intensive Care Unit: A Short Narrative Review of What We Know in 2024.Neonatology · 2024Review
- Pulmonary Surfactant in Adult ARDS: Current Perspectives and Future Directions.Diagnostics (Basel, Switzerland) · 2023Review
- Clinical decision thresholds for surfactant administration in preterm infants: a systematic review and network meta-analysis.EClinicalMedicine · 2023Article
Corrections and comments
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Authors and funding
7 authors at 7 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The ideal threshold at which surfactant administration in preterm neonates with respiratory distress syndrome (RDS) is most beneficial is contentious. The aim of this systematic review was to determine the optimal clinical criteria to guide surfactant administration in preterm neonates with RDS. Methods: The systematic review was registered in PROSPERO (CRD42022309433). Medline, Embase, CENTRAL and CINAHL were searched from inception till 16th May 2023. Only randomized controlled trials (RCTs) were included. A Bayesian random effects network meta-analysis (NMA) evaluating 33 interventions was performed. The primary outcome was requirement of invasive mechanical ventilation (IMV) within 7 days of life. Findings: 58 RCTs were included. In preterm neonates ≤30 weeks after adjusting for the confounding factor of modality of surfactant administration, an arterial alveolar oxygen tension ratio (aAO Interpretation: Surfactant administration may be considered in preterm neonates of ≤30 weeks' with RDS if the FiO Funding: None.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.