Evidence map›Paper›PMID 37538309›Full record

ArticleFrontiers in medicine2023

Accelerated cystogenesis by dietary protein load is dependent on, but not initiated by kidney macrophages.

Randee Sedaka, Jifeng Huang, Shinobu Yamaguchi, Caleb Lovelady, Jung-Shan Hsu, Sejal Shinde, Malgorzata Kasztan, David K Crossman, Takamitsu Saigusa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Intestinal barrier function declines during polycystic kidney disease progression.American journal of physiology. Renal physiology · 2025
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Randee SedakaSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Jifeng HuangSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Shinobu YamaguchiSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Caleb LoveladySection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Jung-Shan HsuSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Sejal ShindeSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Malgorzata KasztanDivision of Pediatric Hematology/Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, United States.
David K CrossmanDepartment of Genetics, University of Alabama at Birmingham, Birmingham, AL, United States.
Takamitsu SaigusaSection of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
University of Alabama at Birmingham · US

Funding

Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Latesha Ellen Elopre · 1988 to 2026
$84.1M
TRAINING IN CELLULAR PHYSIOLOGY MEMBRANE TRANSPORTT32DK007545 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUTIERREZ, ORLANDO M · 1987 to 2023
$4.5M
The Role of Wheat-Gluten in Polycystic Kidney DiseaseR01DK132028 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Takamitsu Saigusa · 2022 to 2026
$1.5M
The Role of Endothelin-1 in Tubular Injury in Sickle Cell DiseaseR00HL144817 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KASZTAN, MALGORZATA · 2021 to 2023
$747k
The role of endothelin-1 in tubular injury in sickle cell diseaseK99HL144817 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KASZTAN, MALGORZATA · 2019 to 2020
$306k
The Role of Kidney Immune Cells in Acceleration of Cyst GrowthR03DK119717 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SAIGUSA, TAKAMITSU · 2019 to 2020
$223k
NHLBI NIH HHS K99 HL144817NHLBI NIH HHS R00 HL144817NIAID NIH HHS P30 AI027767NIDDK NIH HHS R01 DK132028NIDDK NIH HHS R03 DK119717NIDDK NIH HHS T32 DK007545
6 · The paper itself

Abstract

Background: Disease severity of autosomal dominant polycystic kidney disease (ADPKD) is influenced by diet. Dietary protein, a recognized cyst-accelerating factor, is catabolized into amino acids (AA) and delivered to the kidney leading to renal hypertrophy. Injury-induced hypertrophic signaling in ADPKD results in increased macrophage (MФ) activation and inflammation followed by cyst growth. We hypothesize that the cystogenesis-prompting effects of HP diet are caused by increased delivery of specific AA to the kidney, ultimately stimulating MФs to promote cyst progression. Methods: Results: Chronic dietary protein load in Conclusion: Chronic dietary protein load-induced renal hypertrophy and accelerated cyst growth in

Indexed as

glutaminehigh proteinmacrophagepolycystic kidney diseaserenal hypertophy

Identifiers

PMID37538309
PMCPMC10394241
OpenAlexW4384827991

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.