Evidence map›Paper›PMID 37538240›Full record

ArticleAvicenna journal of medical biotechnology

Higher Improvement of Cardiac Function Following Myocardial Infarction using Menstrual Blood Stromal/Stem Cells (MenSCs) Suspended in Conditioned Medium

Mahmood Manshori, Somaieh Kazemnejad, Nasim Naderi, Abolfazl Shirazi, Maedeh Arabian, Marzieh Eghtedar Doost, Maryam Darzi, Samaneh Montazeri, Nahid Aboutaleb, Hannaneh Golshahi

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Article in Avicenna journal of medical biotechnology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mahmood ManshoriFaculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.
Somaieh KazemnejadNanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Nasim NaderiRajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
Abolfazl ShiraziReproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Maedeh ArabianRajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
Marzieh Eghtedar DoostNanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Maryam DarziNanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Samaneh MontazeriNanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Nahid AboutalebPhysiology Research Center, Iran University of Medical Science, Tehran, Iran.
Hannaneh GolshahiNanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: To evaluate the efficiency of Menstrual blood Stromal/Stem Cells (MenSCs) administration in Myocardial Infarction (MI), the effects of MenSCs and their derived conditioned Medium (CM) on cardiac function in MI rat model was assessed. Methods: Animals were divided into four groups including sham group, MI group, MenSCs derived CM group (CM group), and MenSCs suspended in CM (MenSCs+CM) group. The injection of different groups was carried out 30 Results: The results showed a significant reduction in scar size after injection of MenSCs+CM compared to MI group. Ejection fraction and fractional shortening of MenSCs+CM group were higher than CM and MI group at day 28. Administration of MenSCs+CM led to much more survival of cardiomyocytes, and prevention of meta-plastic development. Moreover, human mitochondrial transfer from MenSCs to cardiomyocytes was seen in group treated by MenSCs+CM. Indeed, MenSCs+CM treatment evoked nuclear factor-κB (NF-κB) down-regulation more than other treatments. Conclusion: MenSCs+CM treatment could significantly ameliorate cardiac function by different mechanisms including inhibition of cartilaginous metaplasia, inhibition of NF-κB and mitochondrial transfer.

Indexed as

Conditioned mediumMenstrual blood stem cellsMetaplasiaMitochondrial transferMyocardial infarction

Identifiers

PMID37538240
PMCPMC10395459

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.