ArticleJournal of physiological anthropology2023
Association of sarcopenia, pre-sarcopenia, and dynapenia with the onset and progression of locomotive syndrome in Japanese older adults: a cross-sectional study.
Article in Journal of physiological anthropology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.
- Association between Dynapenia and Multimorbidity in Community-Dwelling Older Adults: A Systematic Review.Annals of geriatric medicine and research · 2024Pooled it
- Pooled it
- The decision support system for preventing non-elderly sarcopenia: Data from NHANES 2011-2018.Sports medicine and health science · 2026Article
- Review
- Associations of Skeletal Muscle Mass and Percent Body Fat with Balance, Gait, and Locomotive Syndrome Risk in Community-dwelling Older Women.Progress in rehabilitation medicine · 2026Article
- Sarcopenia in the Aging Process: Pathophysiological Mechanisms, Clinical Implications, and Emerging Therapeutic Approaches.International journal of molecular sciences · 2025Review
- Impact of dynapenia, presarcopenia and sarcopenia in chronic obstructive pulmonary disease: a prospective cohort study.BMJ open respiratory research · 2025Article
- Association between Central Nervous System Drugs and Femoral Fracture Risk in Japanese Individuals ≥80 Years Old: A Case-crossover Study.Internal medicine (Tokyo, Japan) · 2025Article
- Dynapenia is associated with a higher risk of depressive symptoms among older adults.Frontiers in public health · 2025Article
- Multimorbidity and Multiple Disabilities: Present Status and the Roles of Rehabilitation.Journal of clinical medicine · 2024Review
- Uremic sarcopenia: the role of intramuscular adipose tissue as a potential early identifier.Frontiers in medicine · 2024Article
- The correlation of gait and muscle activation characteristics with locomotion dysfunction grade in elderly individuals.Frontiers in bioengineering and biotechnology · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSarcopenia commonly occurs in older adults with motor disorders requiring long-term care, and the clinical features of sarcopenia are associated with locomotive syndrome. Dynapenia is the age-related loss of muscle strength. However, the association of sarcopenia and dynapenia with the onset and progression of locomotive syndrome in older adults remains unknown. The current study aimed to determine the association of sarcopenia, pre-sarcopenia, and dynapenia with the onset and progression of locomotive syndrome in Japanese older adults.
methodsThis study included older females (n = 264, 73.9 ± 5.8 years) and males (n = 92, 76.3 ± 6.1 years). Sarcopenia was defined as low muscle function and mass; pre-sarcopenia was defined as low muscle mass with normal muscle function; and dynapenia was defined as low muscle function without low muscle mass. Locomotive syndrome (stage 0-2) severity was determined using the stand-up test, the two-step test, and the 25-question geriatric locomotive function scale. Logistic regression analysis was performed to determine the relationship between sarcopenia category and locomotive syndrome stages.
resultsAge (1.208, 95% confidence interval (CI) 1.124-1.298), sex (2.455, 95% CI 1.241-4.856), and BMI (1.211, 95% CI 1.077-1.361) were significant variables for determining locomotive syndrome stage ≥ 1, whereas pre-sarcopenia (0.543, 95% CI 0.331-0.891) and sarcopenia (1.664, 95% CI 1.005-2.755) were significant variables for determining locomotive syndrome stage 2.
conclusionsOnly sarcopenia was associated with locomotive syndrome progression, while low muscle mass or low muscle function was not associated with locomotive syndrome. Gaining muscle mass accompanied by an increased muscle function for older adults is warranted to prevent locomotive syndrome progression in the super-aged society.
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