Evidence map›Paper›PMID 37537186›Full record

ArticleScientific data2023

DIPS-Plus: The enhanced database of interacting protein structures for interface prediction.

Alex Morehead, Chen Chen, Ada Sedova, Jianlin Cheng

Open access · goldAbstract readDataset
In one paragraph

Article in Scientific data, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
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  14. Beyond sequence: Structure-based machine learning.Computational and structural biotechnology journal · 2023
    Review
  15. High-Performance Deep Learning Toolbox for Genome-Scale Prediction of Protein Structure and Function.Workshop on Machine Learning in HPC Environments. Workshop on Machine Learning in HPC Environments · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Alex MoreheadUniversity of Missouri, Electrical Engineering & Computer Science, Columbia, MO, 65211, USA. acmwhb@umsystem.edu.ORCID http://orcid.org/0000-0002-0586-6191
Chen ChenUniversity of Missouri, Electrical Engineering & Computer Science, Columbia, MO, 65211, USA.
Ada SedovaOak Ridge National Laboratory, Oak Ridge, TN, 37830, USA.ORCID http://orcid.org/0000-0002-8233-3057
Jianlin ChengUniversity of Missouri, Electrical Engineering & Computer Science, Columbia, MO, 65211, USA.ORCID http://orcid.org/0000-0003-0305-2853
University of Missouri · USOak Ridge National Laboratory · US

Funding

Integrated Prediction of Protein Struture at 1D, 2D and 3D LevelsR01GM093123 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI CHENG, JIANLIN · 2010 to 2023
$3.8M
Deep learning methods for automated and accurate reconstruction of protein structures from cryo-EM image dataR01GM146340 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI CHENG, JIANLIN · 2022 to 2025
$1.4M
NIGMS NIH HHS R01 GM093123NIGMS NIH HHS R01 GM146340
6 · The paper itself

Abstract

In this work, we expand on a dataset recently introduced for protein interface prediction (PIP), the Database of Interacting Protein Structures (DIPS), to present DIPS-Plus, an enhanced, feature-rich dataset of 42,112 complexes for machine learning of protein interfaces. While the original DIPS dataset contains only the Cartesian coordinates for atoms contained in the protein complex along with their types, DIPS-Plus contains multiple residue-level features including surface proximities, half-sphere amino acid compositions, and new profile hidden Markov model (HMM)-based sequence features for each amino acid, providing researchers a curated feature bank for training protein interface prediction methods. We demonstrate through rigorous benchmarks that training an existing state-of-the-art (SOTA) model for PIP on DIPS-Plus yields new SOTA results, surpassing the performance of some of the latest models trained on residue-level and atom-level encodings of protein complexes to date.

Indexed as

Amino AcidsProteinsDatabases, ProteinMachine LearningSalicylates3,5-diisopropylsalicylic acidAmino AcidsProteinsSalicylates

Identifiers

PMID37537186
PMCPMC10400622
OpenAlexW3171236517

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.