Evidence map›Paper›PMID 37536971›Full record

ArticleBMJ open2023

Multicohort cross-sectional study of cognitive and behavioural digital biomarkers in neurodegeneration: the Living Lab Study protocol.

Mark Crook-Rumsey, Sarah J C Daniels, Subati Abulikemu, Helen Lai, Adrien Rapeaux, Charalambos Hadjipanayi, Eyal Soreq, Lucia M Li, James Bashford, Julian Jeyasingh-Jacob and 6 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Mark Crook-RumseyUK Dementia Research Institute, Basic and Clinical Neuroscience, King's College London, London, UK mark.crook-rumsey@ukdri.ac.uk s.haar@imperial.ac.uk.ORCID 0000-0003-3031-3502
Sarah J C DanielsUK Dementia Research Institute, Care Research and Technology Centre, Imperial College London, London, UK.
Subati AbulikemuUK Dementia Research Institute, Care Research and Technology Centre, Imperial College London, London, UK.
Helen LaiUK Dementia Research Institute, Care Research and Technology Centre, Imperial College London, London, UK.
Adrien RapeauxUK Dementia Research Institute, Care Research and Technology Centre, Imperial College London, London, UK.
Charalambos HadjipanayiUK Dementia Research Institute, Care Research and Technology Centre, Imperial College London, London, UK.
Eyal SoreqUK Dementia Research Institute, Care Research and Technology Centre, Imperial College London, London, UK.
Lucia M LiUK Dementia Research Institute, Care Research and Technology Centre, Imperial College London, London, UK.
James BashfordUK Dementia Research Institute, Basic and Clinical Neuroscience, King's College London, London, UK.
Julian Jeyasingh-JacobUK Dementia Research Institute, Care Research and Technology Centre, Imperial College London, London, UK.
Dragos C GruiaUK Dementia Research Institute, Care Research and Technology Centre, Imperial College London, London, UK.ORCID 0000-0003-0979-0953
Damion LambertUK Dementia Research Institute, Care Research and Technology Centre, Imperial College London, London, UK.
Rimona WeilNational Hospital for Neurology and Neurosurgery, UCLH, London, UK.
Adam HampshireUK Dementia Research Institute, Care Research and Technology Centre, Imperial College London, London, UK.
David J SharpUK Dementia Research Institute, Care Research and Technology Centre, Imperial College London, London, UK.
Shlomi HaarUK Dementia Research Institute, Care Research and Technology Centre, Imperial College London, London, UK mark.crook-rumsey@ukdri.ac.uk s.haar@imperial.ac.uk.ORCID 0000-0003-2213-6585
UK Dementia Research Institute · GBKing's College London · GBNational Hospital for Neurology and Neurosurgery · GBUniversity of Surrey · GB

Funding

Medical Research Council UKDRI-7004
6 · The paper itself

Abstract

INTRODUCTION AND

aimsDigital biomarkers can provide a cost-effective, objective and robust measure for neurological disease progression, changes in care needs and the effect of interventions. Motor function, physiology and behaviour can provide informative measures of neurological conditions and neurodegenerative decline. New digital technologies present an opportunity to provide remote, high-frequency monitoring of patients from within their homes. The purpose of the living lab study is to develop novel digital biomarkers of functional impairment in those living with neurodegenerative disease (NDD) and neurological conditions. METHODS AND ANALYSIS: The Living Lab study is a cross-sectional observational study of cognition and behaviour in people living with NDDs and other, non-degenerative neurological conditions. Patients (n≥25 for each patient group) with dementia, Parkinson's disease, amyotrophic lateral sclerosis, mild cognitive impairment, traumatic brain injury and stroke along with controls (n≥60) will be pragmatically recruited. Patients will carry out activities of daily living and functional assessments within the Living Lab. The Living Lab is an apartment-laboratory containing a functional kitchen, bathroom, bed and living area to provide a controlled environment to develop novel digital biomarkers. The Living Lab provides an important intermediary stage between the conventional laboratory and the home. Multiple passive environmental sensors, internet-enabled medical devices, wearables and electroencephalography (EEG) will be used to characterise functional impairments of NDDs and non-NDD conditions. We will also relate these digital technology measures to clinical and cognitive outcomes. ETHICS AND DISSEMINATION: Ethical approvals have been granted by the Imperial College Research Ethics Committee (reference number: 21IC6992). Results from the study will be disseminated at conferences and within peer-reviewed journals.

Indexed as

Cognitive DysfunctionNeurodegenerative DiseasesActivities of Daily LivingBiomarkersCognitionCross-Sectional StudiesHumansObservational Studies as TopicBiomarkersdementianeurologyneuropathologyneurophysiologyprotocols & guidelinestelemedicine

Identifiers

PMID37536971
PMCPMC10401246
OpenAlexW4385525217

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.