SynthesisBMJ open2023
Adverse childhood experiences, the risk of pregnancy complications and adverse pregnancy outcomes: a systematic review and meta-analysis.
Synthesis in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 46 citations in OpenAlex.
- Exploring trauma-informed prenatal care preferences through diverse pregnant voices.BMC health services research · 2025Trial
- Mapping links between childhood maltreatment and biopsychosocial health in pregnancy: a network analysis.Archives of women's mental health · 2026Article
- The Impact of Stress, Trauma, and Violence on Well-Being and Physical Health.Research in nursing & health · 2026Article
- Migraine, comorbidity, and risks of severe maternal and neonatal morbidity or mortality: a population-based cohort study.American journal of epidemiology · 2026Article
- Improving Neonatal Adverse Childhood Experiences (ACEs) Screening in the NICU: A Quality Improvement Initiative.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Associations between maternal adverse childhood experiences and children's physical health conditions: A longitudinal study.Public health in practice (Oxford, England) · 2026Article
- Prenatal clinicians' perspectives on trauma-informed care competency and training.BMC medical education · 2026Article
- Childhood adversity, benevolent experiences, and perceived stress among pregnant women in Mexico: psychosocial determinants of maternal well-being in a middle-income setting.BMC pregnancy and childbirth · 2026Observational
- Maternal adverse childhood experiences and prenatal stress: Intergenerational transmission and offspring mental health in the ECHO Cohort.Psychological medicine · 2026Article
- Effects of stressful life events on ART treatment outcomes: a prospective study on the role of individual and personality characteristics and psychological health conditions.Frontiers in psychology · 2026Article
- Reduced Adherence to Antiretroviral Therapy in Pregnant Women With HIV With Intimate Partner Violence in the United States.Open forum infectious diseases · 2026Article
- Comparison of the ACE-Q and CTES: A study of childhood trauma and perinatal depression.Journal of affective disorders · 2026Article
- Adverse Childhood Experiences and Antenatal Depression: The Mediating Role of Social Support.Maternal and child health journal · 2025Article
- Adverse childhood experiences, resilience, and substance use during early pregnancy.Preventive medicine · 2025Article
- Maternal Adverse Childhood Experiences and Delayed Initiation of Complementary Foods: A Nationwide Online Cohort Study.Nutrients · 2025Article
- Reframing obstetric care through a trauma-informed lens: A narrative review of trauma-informed principles and clinical applications.Pregnancy (Hoboken, N.J.) · 2025Review
- Associations of adverse childhood experiences (ACE) with pregnancy outcomes in people with cardiac disease.European journal of obstetrics, gynecology, and reproductive biology · 2025Article
- Influence on Consultation Behavior of Pregnant and Postpartum Women in Japan: Insights from a Nation-Wide Survey.Healthcare (Basel, Switzerland) · 2025Article
- Variations in adverse pregnancy and birth outcomes among Latin American and Caribbean-Born birthing people by region of origin, California birth cohort, 2007-2020.BMC pregnancy and childbirth · 2025Article
- Optimizing Psychological Health Across the Perinatal Period: An Update on Maternal Cardiovascular Health: A Scientific Statement From the American Heart Association.Journal of the American Heart Association · 2025Review
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdverse childhood experiences (ACEs) have a profound negative impact on health. However, the strength of the association between ACEs and pregnancy complications and adverse pregnancy outcomes is not well quantified or understood.
objectiveTo conduct a systematic review and meta-analysis of the association between ACEs and risk of pregnancy complications and adverse pregnancy outcomes. SEARCH STRATEGY: A comprehensive search was conducted using PubMed, Embase, CINAHL, PsycINFO, ClinicalTrials.gov and Google scholar up to July 2022. DATA COLLECTION AND ANALYSIS: Two reviewers independently conducted the screening and quality appraisal using a validated tool. Meta-analysis using the quality-effects model on the reported odds ratio (OR) was conducted. Heterogeneity and inconsistency were examined using the I
results32 studies from 1508 met a priori inclusion criteria for systematic review, with 21 included in the meta-analysis. Pooled analyses showed that exposure to ACEs increased the risk of pregnancy complications (OR 1.37, 95% CI 1.20 to 1.57) and adverse pregnancy outcomes (OR 1.31, 95% CI 1.17 to 1.47). In sub-group analysis, maternal ACEs were associated with gestational diabetes mellitus (OR 1.39, 95% CI 1.11 to 1.74), antenatal depression (OR 1.59, 95% CI 1.15 to 2.20), low offspring birth weight (OR 1.27, 95% CI 1.02 to 1.47), and preterm delivery (OR 1.41, 95% CI 1.16 to 1.71).
conclusionThe results suggest that exposure to ACEs increases the risk of pregnancy complications and adverse pregnancy outcomes. Preventive strategies, screening and trauma-informed care need to be examined to improve maternal and child health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.