ArticleGenes & development2023
RUNX1 is required in granulocyte-monocyte progenitors to attenuate inflammatory cytokine production by neutrophils.
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Article in Genes & development, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 24 citations in OpenAlex.
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- GATA2 decommissioning of enhancers: A mechanism to constrain inflammatory signaling.Cell reports · 2025Article
- Tumor-associated neutrophils and neutrophil extracellular traps in lung cancer: antitumor/protumor insights and therapeutic implications.Medical oncology (Northwood, London, England) · 2025Review
- Correlation Between miR-27a-3p Polymorphisms and Peri-Implantitis Susceptibility: A Case-Control Study.International dental journal · 2025Article
- Dual mechanism of inflammation sensing by the hematopoietic progenitor genome.Science advances · 2025Article
- A Novel Protein NAB1-356 Encoded by circRNA circNAB1 Mitigates Atrial Fibrillation by Reducing Inflammation and Fibrosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- [Research Progress of Tumor-associated Neutrophils in the Occurrence and Development of Lung Cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2025Review
- Targeting the CD74 signaling axis suppresses inflammation and rescues defective hematopoiesis inScience translational medicine · 2025Article
- Functional and Practical Insights Into the Genetic Basis of Takayasu Arteritis.ACR open rheumatology · 2025Review
- Article
- Dysregulated innate immune signaling cooperates with RUNX1 mutations to transform an MDS-like disease to AML.iScience · 2024Article
- Altered platelet-megakaryocyte endocytosis and trafficking of albumin and fibrinogen in RUNX1 haplodeficiency.Blood advances · 2024Article
- RUN(X) out of blood: emerging RUNX1 functions beyond hematopoiesis and links to Down syndrome.Human genomics · 2023Review
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Authors and funding
16 authors at 5 institutions in 2 countries.
Alexandra U ZezulinDepartment of Cell and Developmental Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Daniel YenDepartment of Cell and Developmental Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Darwin YeDepartment of Radiation Oncology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Elizabeth D HowellDepartment of Cell and Developmental Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Erica BrescianiOncogenesis and Development Section, Division of Intramural Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Jamie DiemerOncogenesis and Development Section, Division of Intramural Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Jian-Gang RenDepartment of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Mohd Hafiz AhmadDepartment of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Lucio H CastillaDepartment of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Ivo P TouwDepartment of Hematology, Erasmus Medical College, Rotterdam 3015CN, the Netherlands.
Andy J MinnDepartment of Radiation Oncology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Wei TongDepartment of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.ORCID 0000-0001-9951-2273
P Paul LiuOncogenesis and Development Section, Division of Intramural Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Kai TanDepartment of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.ORCID 0000-0002-9104-5567
Wenbao YuDepartment of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; nancyas@upenn.edu yuw1@chop.edu.
Nancy A SpeckDepartment of Cell and Developmental Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; nancyas@upenn.edu yuw1@chop.edu.ORCID 0000-0002-1893-582X
Cancer Research Institute · USChildren's Hospital of Philadelphia · USNational Institutes of Health · USUniversity of Massachusetts Chan Medical School · USErasmus MC · NL
Funding
GENETIC ANALYSIS OF ZEBRAFISH EMBRYO DEVELOPMENTZIAHG000102 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI LIU, PAUL · 2009 to 2025
$17.1MHEMATOLOGY CLINICAL RESEARCH TRAINING PROGRAMT32HL007439 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LAWRENCE F BRASS, PETER S KLEIN · 1985 to 2026
$17.1MBiochemistry of Leukemia Virus Core-Binding FactorR01HL091724 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI SPECK, NANCY · 2008 to 2024
$8.3MExpansion of cardiac and hematopoietic progenitors by Wnt and NotchU01HL100405 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI EPSTEIN, JONATHAN A., MORRISEY, EDWARD E · 2009 to 2015
$8.1MGraduate Training in Developmental BiologyT32HD083185 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI Michael Granato, Foteini Mourkioti · 2015 to 2026
$4.0MRegulation of Ribosome Biogenesis in Hematopoietic Stem CellsR01DK127738 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI TONG, WEI · 2020 to 2024
$3.0MNovel Regulation of Oncogenic NRAS Signaling in Myeloid MalignanciesR01CA271523 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI Wei Tong · 2022 to 2026
$2.7MMechanism of Lnk function in cytokin receptor signalingK01CA115679 · NCI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI TONG, WEI · 2005 to 2009
$727kIdentifying necessary chromatin states and targets for hemogenic specification and reprogrammingF31HL150952 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI HOWELL, ELIZABETH · 2020 to 2021
$70kDetermining how RUNX1 regulates the inflammatory response in neutrophilsF30DK128926 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI ZEZULIN, ALEXANDRA · 2022 to 2023
$43kNCI NIH HHS K01 CA115679NCI NIH HHS R01 CA271523NHLBI NIH HHS F31 HL150952NHLBI NIH HHS R01 HL091724NHLBI NIH HHS T32 HL007439NHLBI NIH HHS U01 HL100405NICHD NIH HHS T32 HD083185NIDDK NIH HHS F30 DK128926NIDDK NIH HHS R01 DK127738
Abstract
The transcription factor RUNX1 is mutated in familial platelet disorder with associated myeloid malignancy (FPDMM) and in sporadic myelodysplastic syndrome and leukemia. RUNX1 was shown to regulate inflammation in multiple cell types. Here we show that RUNX1 is required in granulocyte-monocyte progenitors (GMPs) to epigenetically repress two inflammatory signaling pathways in neutrophils: Toll-like receptor 4 (TLR4) and type I interferon (IFN) signaling. RUNX1 loss in GMPs augments neutrophils' inflammatory response to the TLR4 ligand lipopolysaccharide through increased expression of the TLR4 coreceptor CD14. RUNX1 binds
Indexed as
NeutrophilsToll-Like Receptor 4ChromatinCore Binding Factor Alpha 2 SubunitCytokinesGuanosine MonophosphateMonocytesSTAT1 Transcription FactorThionucleotidesChromatinCore Binding Factor Alpha 2 SubunitCytokinesguanosine 5'-monophosphorothioateGuanosine MonophosphateSTAT1 Transcription FactorThionucleotidesToll-Like Receptor 4hematopoiesisinflammationretroelementsRUNX1transposable elements
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.