Evidence map›Paper›PMID 37536921›Full record

ArticleJournal of epidemiology and community health2023

The potential of intervening on childhood adversity to reduce socioeconomic inequities in body mass index and inflammation among Australian and UK children: A causal mediation analysis.

Naomi Priest, Shuaijun Guo, Dawid Gondek, Meredith O'Connor, Margarita Moreno-Betancur, Sarah Gray, Rebecca Lacey, David P Burgner, Sue Woolfenden, Hannah Badland and 4 more

Open access · greenAbstract read
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In one paragraph

Article in Journal of epidemiology and community health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 3 countries.

Naomi PriestCentre for Social Research and Methods, Australian National University, Canberra, Australian Capital Territory, Australia naomi.priest@anu.edu.au.ORCID 0000-0002-2246-0644
Shuaijun GuoCentre for Community Child Health, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.ORCID 0000-0001-5737-4765
Dawid GondekResearch Department of Epidemiology and Public Health, University College London, London, UK.ORCID 0000-0002-0321-7649
Meredith O'ConnorDepartment of Pediatrics, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-8787-7352
Margarita Moreno-BetancurDepartment of Pediatrics, The University of Melbourne, Melbourne, Victoria, Australia.
Sarah GrayCentre for Community Child Health, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Rebecca LaceyResearch Department of Epidemiology and Public Health, University College London, London, UK.ORCID 0000-0002-3510-0795
David P BurgnerDepartment of Pediatrics, The University of Melbourne, Melbourne, Victoria, Australia.
Sue WoolfendenPopulation Child Health Research Group, University of New South Wales, Sydney, New South Wales, Australia.ORCID 0000-0002-6954-5071
Hannah BadlandCentre for Urban Research, RMIT University, Melbourne, Victoria, Australia.
Gerry RedmondCollege of Business, Government and Law, Flinders University, Adelaide, South Australia, Australia.
Markus JuonalaDepartment of Medicine, University of Turku, Turku, Finland.
Katherine LangeDepartment of Pediatrics, The University of Melbourne, Melbourne, Victoria, Australia.
Sharon GoldfeldCentre for Community Child Health, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.ORCID 0000-0001-6520-7094
The University of Melbourne · AUUniversity College London · GBAustralian National University · AUFlinders University · AURMIT University · AURoyal Children's Hospital · AUUniversity of Turku · FIUNSW Sydney · AU

Funding

Maternal overnutrition and offspring fat mass, metabolic and vascular function.R01DK077659 · NIDDK · UNIVERSITY OF BRISTOL · PI LAWLOR, DEBORAH ANNE · 2006 to 2009
$986k
Medical Research CouncilNIDDK NIH HHS R01 DK077659Wellcome TrustWellcome Trust 07467/Z/05/ZWellcome Trust 217065/Z/19/Z
6 · The paper itself

Abstract

backgroundLower maternal education is associated with higher body mass index (BMI) and higher chronic inflammation in offspring. Childhood adversity potentially mediates these associations. We examined the extent to which addressing childhood adversity could reduce socioeconomic inequities in these outcomes.

methodsWe analysed data from two early-life longitudinal cohorts: the Longitudinal Study of Australian Children (LSAC; n=1873) and the UK Avon Longitudinal Study of Parents and Children (ALSPAC; n=7085). EXPOSURE: low/medium (below university degree) versus high maternal education, as a key indicator of family socioeconomic position (0-1 year). OUTCOMES: BMI and log-transformed glycoprotein acetyls (GlycA) (LSAC: 11-12 years; ALSPAC: 15.5 years). Mediator: multiple adversities (≥2/<2) indicated by family violence, mental illness, substance abuse and harsh parenting (LSAC: 2-11 years; ALSPAC: 1-12 years). A causal mediation analysis was conducted.

resultsLow/medium maternal education was associated with up to 1.03 kg/m

conclusionsOur findings in both cohorts suggest that slight reductions in socioeconomic inequities in children's BMI and inflammation could be achieved by addressing childhood adversities. Public health and social policy efforts should help those affected by childhood adversity, but also consider underlying socioeconomic conditions that drive health inequities.

Indexed as

Adverse Childhood ExperiencesMediation AnalysisAustraliaBody Mass IndexChildEducational StatusHumansInflammationLongitudinal StudiesParentingUnited KingdomCARDIOVASCULAR DISEASESCHILD HEALTHHealth inequalitiesLONGITUDINAL STUDIESPUBLIC HEALTH

Identifiers

PMID37536921
PMCPMC10527996
OpenAlexW4385542107

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.