Evidence map›Paper›PMID 37536860›Full record

ReviewAdvances in surgery2023

What Is the Role of the Gut in Wound Infections?

Sanjiv Hyoju, Kaylie Machutta, Monika A Krezalek, John C Alverdy

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Sanjiv HyojuDepartment of Surgery, University of Chicago, Pritzker School of Medicine, 5841 South Maryland, Chicago, IL 60637, USA.
Kaylie MachuttaUniversity of Nevada, Reno School of Medicine, 1664 North Virginia Street, Reno, NV 89557, USA.
Monika A KrezalekNorthshore University Health Systems, 1000 Central Street Suite 800, Evanston, IL 60201, USA.
John C AlverdyDepartment of Surgery, University of Chicago, Pritzker School of Medicine, 5841 South Maryland, Chicago, IL 60637, USA. Electronic address: jalverdy@surgery.bsd.uchicago.edu.
University of Chicago · USNorthShore University HealthSystem · USUniversity of Nevada, Reno · US

Funding

PSEUDOMONAS'EFFECTS ON THE GUT BARRIER FROM SURGERYR01GM062344 · NIGMS · UNIVERSITY OF CHICAGO · PI ALVERDY, JOHN C · 2001 to 2025
$9.2M
NIGMS NIH HHS R01 GM062344
6 · The paper itself

Abstract

Emerging evidence suggest a major role for the gut microbiome in wound infections. A Trojan Horse mechanism of surgical site infections has been hypothesized to occur when pathogens in the gut, gums, and periodontal areas enter an immune cell and silently travel to the wound site where they release their infectious payload. Genetic tracking of microbes at the strain level is now possible with genetic sequencing techniques and can clarify the origin of microbes that cause wound infections. An emerging field of dietary prehabilitation to modulate the microbiome before surgery is being described to improve infection-related outcomes from surgery.

Indexed as

Gastrointestinal MicrobiomeSurgical Wound InfectionHumansAntibioticsFecal transplantProbioticsSurgical site infectionTrojan horse

Identifiers

PMID37536860
PMCPMC10837732
OpenAlexW4381951280

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.