Evidence map›Paper›PMID 37536302›Full record

ReviewJournal of vascular research2023

Vascular Dysfunction in Polycystic Kidney Disease: A Mini-Review.

Melissa R Dennis, Paulo W Pires, Christopher T Banek

Open access · greenAbstract readReview
In one paragraph

Review in Journal of vascular research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Renal blood flow and progression to kidney failure in ADPKD.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026
    Observational
  2. Review
  3. Review
  4. Developmental nicotine exposure alters cardiovascular structure and function in neonatal and juvenile rats.American journal of physiology. Heart and circulatory physiology · 2024
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Impact of aging on vascular ion channels: perspectives and knowledge gaps across major organ systems.American journal of physiology. Heart and circulatory physiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Melissa R DennisDepartment of Physiology, University of Arizona Health Sciences Center, Tucson, Arizona, USA.
Paulo W PiresDepartment of Physiology, University of Arizona Health Sciences Center, Tucson, Arizona, USA.
Christopher T BanekDepartment of Physiology, University of Arizona Health Sciences Center, Tucson, Arizona, USA.
University of Arizona · US

Funding

National Coordinating Center (NCC) for the Polycystic Kidney Disease (PKD) Research and Translation Core CentersU24DK126110 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI Terry J Watnick · 2020 to 2026
$7.4M
Role of Endothelial K+ Channels in Age-Related DementiaR01AG073230 · NIA · LOMA LINDA UNIVERSITY · PI Erik J. Behringer, Paulo W Pires · 2022 to 2026
$3.3M
Renal Denervation to Treat Polycystic Kidney Disease: Mechanisms and MediatorsR01DK135573 · NIDDK · UNIVERSITY OF MINNESOTA · PI Christopher T Banek · 2024 to 2026
$1.8M
Cerebral functional hyperemia responses induced by capillary NMDA receptors are disrupted by amyloid-beta accumulationR00HL140106 · NHLBI · UNIVERSITY OF ARIZONA · PI PIRES, PAULO W · 2019 to 2021
$747k
Renal Denervation To Treat Hypertension: Mechanisms and MediatorsR00HL141650 · NHLBI · UNIVERSITY OF ARIZONA · PI BANEK, CHRISTOPHER T · 2019 to 2021
$747k
NHLBI NIH HHS R00 HL140106NHLBI NIH HHS R00 HL141650NIA NIH HHS R01 AG073230NIDDK NIH HHS L40 DK137705NIDDK NIH HHS R01 DK135573NIDDK NIH HHS U24 DK126110
6 · The paper itself

Abstract

Polycystic kidney disease (PKD) is one of the most common hereditary kidney diseases, which is characterized by progressive cyst growth and secondary hypertension. In addition to cystogenesis and renal abnormalities, patients with PKD can develop vascular abnormalities and cardiovascular complications. Progressive cyst growth substantially alters renal structure and culminates into end-stage renal disease. There remains no cure beyond renal transplantation, and treatment options remain largely limited to chronic renal replacement therapy. In addition to end-stage renal disease, patients with PKD also present with hypertension and cardiovascular disease, yet the timing and interactions between the cardiovascular and renal effects of PKD progression are understudied. Here, we review the vascular dysfunction found in clinical and preclinical models of PKD, including the clinical manifestations and relationship to hypertension, stroke, and related cardiovascular diseases. Finally, our discussion also highlights the critical questions and emerging areas in vascular research in PKD.

Indexed as

HypertensionKidney Failure, ChronicPolycystic Kidney DiseasesStrokeHumansKidneyAutosomal dominant polycystic kidney diseaseAutosomal recessive polycystic kidney diseaseEnd stage renal diseaseFibrocystinHypertensionPolycystic kidney diseasePolycystinVascular dysfunctionWire myography

Identifiers

PMID37536302
PMCPMC10947982
OpenAlexW4385564671

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.