Evidence map›Paper›PMID 37536274›Full record

ArticleInflammatory bowel diseases2023

Exploring Colitis through Dynamic T Cell Adoptive Transfer Models.

Wenjing Yang, Yingzi Cong

Open access · greenAbstract read
In one paragraph

Article in Inflammatory bowel diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Wenjing YangDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.ORCID 0000-0003-1541-1892
Yingzi CongDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.ORCID 0000-0003-4167-7395
The University of Texas Medical Branch at Galveston · US

Funding

Gut microbiota metabolite sensing licenses IEC to cross talk with T cells to inhibit intestinal inflammationR01DK135193 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Yingzi Cong · 2023 to 2026
$2.2M
GPR120 regulation of inflammatory bowel diseaseR01DK125011 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CONG, YINGZI · 2020 to 2022
$1.5M
Microbiota metabolites, GPR, and inflammatory bowel diseasesR01DK112436 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CONG, YINGZI · 2017 to 2020
$1.4M
NIDDK NIH HHS R01 DK135193
6 · The paper itself

Abstract

Numerous animal models of colitis have provided important insights into the pathogenesis of inflammatory bowel disease (IBD), contributing to a better understanding of the underlying mechanisms for IBD. As aberrant CD4+ T cell responses play a critical role in the pathogenesis and development of IBD, T cell adoptive transfer models of colitis have become a valuable tool in investigating the immunopathogenesis of intestinal inflammation. While the adoptive transfer of CD4+ CD45RBhi T cells into immunedeficient recipient mice was the first discovered and is currently the most widely used model, several variations of the T cell transfer model have also been developed with distinct features. Here, we describe the history, principle, and characteristics of adoptive transfer colitis models and discuss their strengths, limitations, and applications.

Indexed as

ColitisInflammatory Bowel DiseasesAdoptive TransferAnimalsCD4-Positive T-LymphocytesDisease Models, AnimalMiceCBir1CD45RBhiTh1Th17Treg

Identifiers

PMID37536274
PMCPMC10547233
OpenAlexW4385515581

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.